《生命科学》 2023, 35(9): 1147-1159

脂质自噬对肝脏脂质代谢的影响及机制研究进展

黄超群 , 刘有华 , 王新霞^*

浙江大学动物科学学院，教育部动物分子营养学重点实验室，农业农村部(华东)动物营 养与饲料重点实验室，浙江省饲料与动物营养重点实验室，杭州 310058

摘　要：

肝脏是机体脂质代谢的枢纽。自噬是真核生物体内高度保守的生物学过程，选择性地清除细胞内脂质的过程被称为脂质自噬，简称脂噬。越来越多的研究表明，脂噬在维持肝脏及全身脂质稳态中发挥重要的调控作用，脂噬功能障碍与肝脏的多种病理、生理过程密切相关。因此，靶向脂噬可能有利于开发新的治疗肝脂代谢紊乱的手段。本文综述了脂噬发生过程以及调节肝脏脂噬的最新进展，并对靶向脂噬治疗肝脂代谢紊乱的研究进行了总结，为理解脂噬的调控机制及其生物学意义提供参考。

通讯作者：王新霞 , Email:xinxiawang@zju.edu.cn

Role and mechanisms of lipophagy on liver lipid metabolism

HUANG Chao-Qun , LIU You-Hua , WANG Xin-Xia^*

Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

Abstract:

The liver is the key regulator of systemic lipid metabolism. Autophagy is a highly conserved biological process in eukaryotes. Lipophagy is a selective type of autophagy which targets lipid droplets for degradation. Studies have shown that lipophagy plays an  important regulatory role in maintaining homeostasis of lipid droplets, and its dysfunction is closely related to a variety of pathological and physiological  processes in the liver. Therefore, targeting lipophagy may serve as a  potential therapeutic strategy for the treatment of hepatic lipid metabolism disorder. This article reviews the  underlying mechanism by which  lipophagy is induced and regulated, and the current findings on targeting lipophagy to counteract abnormal lipid metabolism, so as to provide a  reference for better understanding the regulatory mechanism of lipophagy and its biological significance.

Communication Author：WANG Xin-Xia , Email:xinxiawang@zju.edu.cn