《生命科学》 2023, 35(9): 1136-1146
宫内母源性糖皮质激素编程子代肝脏发育及相关疾病易感
摘 要：
胎血基础糖皮质激素(glucocorticoid, GC) 主要来自母体，其水平是决定胎儿多器官发育及功能成熟的关键。然而，孕期母体受内、外环境刺激后，其内源性GC 水平或胎盘GC 屏障功能会发生改变，进而引起宫内母源性GC 水平异常。大量研究发现，宫血GC 水平过高或过低均可导致子代肝脏发育及功能异常，导致出生后相关疾病易感，这主要与GC 调控的信号通路、转录因子及表观遗传修饰的改变有关。迄今，宫内母源性GC 水平对子代肝脏发育的影响及其编程机制尚未系统阐明。本文结合最新流行病学和
实验研究，综述了宫内时期肝脏的生理发育过程及内源性GC 的调控作用，重点介绍宫内母源性GC 水平改变对子代肝脏发育及相关疾病易感性的影响，并阐明其网络调控机制，这对于解析肝脏生理发育与病理改变并探究相关疾病易感的宫内起源机制具有重要意义。
通讯作者：汪 晖 , Email:wanghui19@whu.edu.cn
Abstract:
Fetal blood glucocorticoid (GC) mainly comes from the mother, and GC level is the key to fetal organ development and functional maturation. However, when prenatally exposed to adverse internal and external environments, the maternal endogenous GC level or the function of placental GC barrier will be changed, thus leading to an abnormal intrauterine GC level, which will cause abnormal development and function in offspring liver, and even predisposition to related diseases after birth. These are found mainly related to signaling pathway, transcription factors and epigenetic modifications regulated by GC. Until now, the effects of maternal GC in utero on offspring liver development and the programming mechanisms have yet to be systematically elucidated. Based on the latest epidemiological and experimental studies, this paper reviewed the physiological development of intrauterine liver and the regulatory mechanism of endogenous GC, focusing on the effects of intrauterine maternal GC level changes on offspring liver development and susceptibility to related diseases, and the regulatory network, which is of great significance to analyze the liver's physiological development and pathological changes and explore the intrauterine origins of the susceptibility of related diseases.
Communication Author：WANG Hui , Email:wanghui19@whu.edu.cn
