《生命科学》 2023, 35(9): 1128-1135

琥珀酸：对能量稳态调节具有多效功能的代谢物

李孟颖¹ , 王振刚¹ , 刘　爽² , 林　海² , 李海芳^1,*

¹山东农业大学生命科学学院，泰安 271018 ²山东农业大学动物科技学院，泰安 271018

摘　要：

琥珀酸是连接三羧酸循环和线粒体呼吸链的重要中间产物，同时也是某些肠道共生菌的重要代谢产物。线粒体和肠道菌来源的琥珀酸均可进入机体循环系统，导致该有机酸水平在生理和病理状态下产生波动。尽管长期以来琥珀酸被认为是一种与炎症相关的危险信号分子，但其还在能量稳态调节中显示多效作用。琥珀酸的多效性除与其来源有关外，还与其作用途径密切相关。本文从琥珀酸的来源、参与能量稳态调节的途径及其与代谢紊乱性疾病间的关系三个方面进行重点论述，以期为全面了解琥珀酸的功能及靶向琥珀酸途径进行代谢性疾病的防治提供重要信息。

通讯作者：李海芳 , Email:haifangli@sdau.edu.cn

Succinate: a pleiotropic metabolite in energy homeostasis

LI Meng-Ying¹ , WANG Zhen-Gang¹ , LIU Shuang² , LIN Hai² , LI Hai-Fang^1,*

¹College of Life Sciences, Shandong Agricultural University, Tai’an 271018, China ²College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai’an 271018, China

Abstract:

Succinate is an important intermediary that connects the tricarboxylic acid cycle with the mitochondrial respiratory chain, which is also a critical metabolite of certain intestinal commensal bacteria. Succinate derived from both mitochondria and gut bacteria will release into the circulation system of hosts, resulting in the fluctuation of this organic acid under physiological and pathological states. Although it has long been considered as a danger signal molecule associated with inflammation, emerging evidence supports a key  pleiotropic role for succinate in regulating energy homeostasis. The pleiotropy of succinate is attributable to its origin as well as its functional pathway. This review focuses on the  origin and the functional pathways of succinate, and its roles in metabolic disorders, aiming to provide full insights on the function of succinate, and further open new avenues for the clinical use of this organic acid in combating  metabolic diseases.

Communication Author：LI Hai-Fang , Email:haifangli@sdau.edu.cn