《生命科学》 2023, 35(8): 1105-1114

成像技术在阿尔茨海默病诊断中的应用

王　健 , 武晓丽^*

天津大学生命科学学院，天津 300072

摘　要：

阿尔茨海默病(Alzheimer’s disease, AD) 是最常见的神经退行性疾病，目前临床尚缺乏有效的治疗方法。由于AD 的病理变化发生在临床症状之前几十年，早期诊断和干预有助于缓解疾病进展。目前，研究正在从基于症状的临床诊断转向基于病理标志物的生物学诊断。本文综述了AD 最常用的早期诊断成像技术，介绍其成像原理、局限性和最新研究进展，并展望了AD 早期诊断未来可能的发展方向。预测多模态成像和诊疗一体化可能是未来AD 研究和临床实践的最佳方案。

通讯作者：武晓丽 , Email:wuxiaoli@tju.edu.cn

Imaging techniques in the diagnosis of Alzheimer’s disease

WANG Jian , WU Xiao-Li^*

School of Life Sciences, Tianjin University, Tianjin 300072, China

Abstract:

Alzheimer’s disease (AD) is the most common neurodegenerative disease for which there is no effective clinical treatment at present. Since pathological changes in AD occured decades before clinical symptoms, early diagnosis and intervention contribute to mitigate the progression of AD. Currently, researches have been shifting from symptom-based clinical diagnosis to biological diagnosis based on pathological markers. In this review, we provide an overview of the most common imaging techniques used for early diagnose in AD, describing the respective imaging principles, limitations and recent research advances. Meanwhile, we prospect the possible future directions for early diagnosis of AD. Predicting multimodal imaging and theranostics may be the best solution for future research and clinical practice in AD.

Communication Author：WU Xiao-Li , Email:wuxiaoli@tju.edu.cn