《生命科学》 2023, 35(8): 1043-1051

外泌体源性环状RNA在肺癌病理进程及诊疗中的研究进展

丁庆凯^1,2,3 , 唐旭东^1,2,3,*

¹广东医科大学生物化学与分子生物学研究所，湛江 524023 ²广东医科大学抗肿瘤活性 物质研发协同创新中心，湛江 524023 ³广东医科大学医学技术学院，东莞 523808

摘　要：

外泌体是具有细胞间信号传递生物学功能的一种脂质双分子层囊泡，其内包含RNA、DNA、蛋白质等生物分子，近年来其在疾病发生发展、早期诊断和治疗等方面的作用被广泛研究。环状RNA (circular RNA, circRNA) 是一类可以存在于外泌体中的单链闭合环状RNA。越来越多的研究表明外泌体源性circRNA 与肺癌的发生发展密切相关，为了更好地了解外泌体源性circRNA 在肺癌病理进程中的作用，本文重点讲述了外泌体源性circRNA 在肺癌增殖、侵袭与转移、免疫逃逸和耐药中的作用，以及其在肺癌诊断、预后评估及治疗方面的研究进展。

通讯作者：唐旭东 , Email:tangxudong2599@126.com

Research progress of exosomal circRNAs in the pathological process and diagnosis and treatment of lung cancer

DING Qing-Kai^1,2,3 , TANG Xu-Dong^1,2,3,*

¹Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China ²Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong Medical University, Zhanjiang 524023, China ³School of Medical Technology, Guangdong Medical University, Dongguan 523808, China

Abstract:

Exosomes are lipid bilayer vesicles that transmit intercellular signals and contain biological molecules such as RNAs, DNAs, and proteins. In recent years, extensive researches have focused on the role of exosomes in pathogenesis, early diagnosis, and treatment of diseases. Circular RNAs (circRNAs) are a class of single-stranded and closed circular RNA that can exist in exosomes. Exosomal circRNAs are shown to play a crucial role in the occurrence and development of lung cancer. In this review, we summarize the role of exosomal circRNAs in cell proliferation, invasion, metastasis, immune escape, and drug resistance, as well as recent progress in diagnosis, prognosis assessment and treatment of lung cancer.

Communication Author：TANG Xu-Dong , Email:tangxudong2599@126.com