《生命科学》 2023, 35(8): 1034-1042

白花丹素抗肿瘤作用机制的研究进展

徐瑞雪¹ , 王　宇^2,*

¹陕西中医药大学基础医学院，咸阳 712046 ²陕西中医药大学医学科研实验中心，咸阳 712046

摘　要：

恶性肿瘤一直是生物医学中的难题，利用放射疗法或化学疗法治疗肿瘤常会引发如呕吐、恶心等不良反应。因此，寻找安全有效治疗肿瘤的替代药物源非常重要。白花丹素(plumbagin, PLB) 是从中草药白花丹根部提取出来的一种生物活性化合物，在肿瘤治疗中具有重要作用，并且有较好的抗癌活性。因此，本文将从肿瘤细胞的增殖、凋亡、转移和侵袭、血管生成、铁死亡过程以及化疗敏感性等六个方面对白花丹素的抗肿瘤作用及相关分子机制的研究进行综述，以期为基于白花丹素的抗肿瘤药物研发和临床应用提供科学参考。

通讯作者：王　宇 , Email:wangyu541ban@sina.com

Research progress on anti-tumor mechanism of plumbagin

XU Rui-Xue¹ , WANG Yu^2,*

¹School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China ²Medical Research Experimental Center, Shaanxi University of Chinese Medicine, Xianyang 712046, China

Abstract:

Malignant tumors have always been a difficult problem in biomedicine. The use of radiotherapy or chemotherapy to treat tumors often causes adverse reactions such as vomiting and nausea. Therefore, it is important to find alternative drug sources for the safe and effective treatment of tumors. Plumbagin is a bioactive compound extracted from the root of the Chinese herbal medicine Plumbagin, which plays an important role in tumor therapy and has good anticancer activity. Therefore, this article reviews the anti-tumor effects and related molecular mechanisms of plumbagin from six aspects, such as tumor cell proliferation, apoptosis, metastasis and invasion, angiogenesis, ferroptosis and chemotherapy sensitivity, in order to provide scientific reference for the development and clinical application of plumbagin.

Communication Author：WANG Yu , Email:wangyu541ban@sina.com