《生命科学》 2023, 35(8): 1023-1033

CircRNA通过铁死亡参与调控疾病发生发展的研究进展

常　琳¹ , 王　莹² , 程文政³ , 杨晨旭³ , 许超千^3,*

¹牡丹江医学院药学院，牡丹江 157400 ²牡丹江医学院基础医学院， 牡丹江 157400 ³哈尔滨医科大学药学院，哈尔滨 150081

摘　要：

环状RNA (circular non-coding RNA, circRNA) 是一类特殊的非编码RNA 分子，呈封闭环状结构，不易受核糖核酸外切酶(ribonuclease R, RNaseR) 影响，表达更稳定且不易降解。CircRNA 可在转录后水平调控基因表达，从而广泛参与多种生理病理过程。铁死亡是一种铁依赖性、由脂质过氧化引起的新型程序性细胞死亡方式。研究表明，circRNA 可以通过调控细胞铁死亡，在癌症、糖尿病并发症、心脑血管疾病、呼吸系统疾病中发挥重要作用。本文通过综述circRNA 在不同疾病中调控细胞铁死亡的作用及机制，为相关疾病的治疗提供新的靶点和思路。

通讯作者：许超千 , Email:xuchaoqian@ems.hrbmu.edu.cn

Research progress on the role of circRNA in diseases through targeting ferroptosis

CHANG Lin¹ , WANG Ying² , CHENG Wen-Zheng³ , YANG Chen-Xu³ , XU Chao-Qian^3,*

¹College of Pharmacy, Mudanjiang Medical University, Mudanjiang 157400, China ²College of Basic Medicine, Mudanjiang Medical University, Mudanjiang 157400, China ³College of Pharmacy, Harbin Medical University, Harbin 150081, China

Abstract:

Circular RNA (circular non-coding RNA, circRNA), a special kind of non-coding RNA with closed circular structure, is more stable and not easy to be digested by ribonuclease R (RNaseR). It is involved in the regulation of gene expression at post-transcriptional level in multiple biological processes including ferroptosis, which is a new type of iron-dependent programmed cell death caused by lipid peroxidation. Studies have shown that circRNAs play an important role in cancer, diabetic complications, cardio-cerebrovascular diseases and respiratory diseases by regulating ferroptosis. In this paper, we review the role and mechanism of circRNA in regulating ferroptosis in different diseases, aiming to provide new therapeutic targets and ideas.

Communication Author：XU Chao-Qian , Email:xuchaoqian@ems.hrbmu.edu.cn