《生命科学》 2023, 35(7): 935-946
邻苯二甲酸酯的生殖毒性及分子机制研究进展
摘 要：
近年来，工业化、城市化的发展以及消费主义的盛行加重了环境污染( 如辐射、重金属污染、空气污染、有机污染等)。这类有害污染物对生物体甚至对其后代造成健康威胁，进而引起全球关注。这类有害的环境污染物被定义为一类干扰体内天然血源性激素的合成分泌，扰乱机体稳态，阻碍生殖发育的内分泌干扰物(endocrine-disrupting chemicals, EDCs)。邻苯二甲酸酯(phthalate esters, PAEs) 作为内分泌干扰物中广泛使用的一种，在多种环境介质中分布存在。该文概括了PAEs 的来源和用途，总结了其对生殖系统的毒性效应，并对其分子作用机制进行了探讨。机体暴露于PAEs 后，核因子E2 相关因子2 (nuclear factor erythroid 2–related factor 2, Nrf2)、核因子-κB (nuclear factor κB, NF-κB) 以及磷脂酰肌醇-3- 激酶(phosphatidylinositol-3-kinase, PI3K)/AKT 信号通路在氧化应激、炎症、凋亡和癌症过程中的作用已被众多研究所证明。未来的研究可以聚焦于这些分子靶标的药物研发上，以减少PAEs 引起的毒性作用。
通讯作者：刘 畅 , Email:changliu@cpu.edu.cn
Abstract:
In recent years, progressive industrialization, urbanization, and consumerism have led to environmental pollution (such as radiation, heavy metal pollution, air pollution, organic pollution, etc.). Such harmful pollutants pose a threat to the health of organisms and even their offspring, causing global concern. Endocrine-disrupting chemicals are defined as a group of widespread exogenous agents that interfere with the synthesis, secretion, transport, metabolism, binding action, or elimination of natural blood-borne hormones that are present in the body and are responsible for homeostasis, and reproduction and developmental processes. As a widely used endocrine disruptors, the phthalate esters (PAEs) are extensively distributed in many environmental matrices. The article provides an overview of the sources and applications of PAEs, summarizes their toxic effects on the reproductive system, and discusses their molecular mechanisms of action. In various studies, the role of nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear factor κB (NF-κB), and phosphatidylinositol-3-kinase (PI3K) /AKT signaling pathways in oxidative stress, inflammation, apoptosis, and cancer after exposure to PAEs have been demonstrated. Future research should focus on drug development of these molecular targets to reduce the toxic effects caused by PAEs.
Communication Author：LIU Chang , Email:changliu@cpu.edu.cn
