《生命科学》 2023, 35(7): 903-909

NLRP3炎症小体活化机制研究进展

张　坦^1,2,*

¹上海体育大学运动健康学院，上海 200438 ²上海体育大学上海市运动与代谢健康前沿科学研究基地，上海 200438

摘　要：

炎症反应是机体应对外源性刺激的一种保护性免疫反应，但过度炎症反应则损伤机体。核苷酸结合寡聚化结构域样受体含pyrin 结构域蛋白3 (nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3, NLRP3) 炎症小体是近年来研究较多的一类多蛋白复合体，其被活化后诱导炎症因子白介素-1β (interleukin-1β, IL-1β) 和白介素-18 (interleukin-18, IL-18) 的合成。NLRP3 炎症小体异常活化导致炎症反应过度，进而促进诸多炎症性疾病发生发展。因此，阐明NLRP3 炎症小体活化机制具有非常重要的价值。本文从胞内离子流动、细胞器改变及代谢调控等多方面对NLRP3 炎症小体活化机制进行综述，以期为炎症相关疾病的防治提供科学理论基础和新思路。

通讯作者：张　坦 , Email:zhangtan@sus.edu.cn

Research progress in the activation of NLRP3 inflammasome

ZHANG Tan^1,2,*

¹School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China ²Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China

Abstract:

Inflammation is a protective immune response to defend exogenous stimulations, however, excessive inflammation is detrimental to the body. NLRP3 inflammasome is a class of multi-protein complex that has been extensively studied in recent years, which is activated to induce the generation of interleukin-1β (IL-1β) and interleukin-18 (IL-18). Abnormal activation of NLRP3 inflammasome leads to excessive inflammatory response, which further promotes the development of many inflammatory diseases. Therefore, it is of great value to elucidate the regulatory mechanisms of NLRP3 inflammasome activation. In this paper, the activation mechanisms are reviewed from the aspects of ion flux, alterations of cellular organelles, and metabolic regulation, hoping to provide theoretical basis and new targets for the prevention and treatment of inflammation-related diseases.

Communication Author：ZHANG Tan , Email:zhangtan@sus.edu.cn