《生命科学》 2023, 35(7): 894-902

长链酰基辅酶A合成酶4的生物学及病理学功能研究进展

万根萌¹ , 杨　旸^1,2 , 李梦焕¹ , 马迁鹤³ , 衣雪洁^1,4,*

¹沈阳体育学院运动健康学院，沈阳 110102 ²上海体育大学运动健康学院，上海 200438 ³辽宁师范大学体育学院，大连 116029 ⁴沈阳体育学院体育社会科学研究中心，沈阳 110102

摘　要：

长链酰基辅酶A合成酶4 (long-chain acyl-CoA synthetase 4, ACSL4) 是多不饱和脂肪酸(polyunsaturated fatty acid, PUFA) 代谢的重要催化酶，广泛存在于合成类固醇的组织中。以往研究报道ACSL4 功能多聚焦于调节脂代谢。近期研究表明ACSL4 与机体胰岛素分泌、骨骼肌蛋白质代谢及机体炎症反应等多种生物学过程密切相关，且ACSL4 可能通过介导铁死亡调控癌症和缺血性脑卒中及急性肾损伤的发生发展。此外，ACSL4 在非酒精性脂肪肝病及肝癌中表达失调，并通过上调mTOR 磷酸化或c-Myc 进而促进肝细胞增殖，提示ACSL4 可能是多种疾病的治疗靶点。本文主要对ACSL4 的生理及病理作用进行综述，以期为相关研究和治疗提供理论依据。

通讯作者：衣雪洁 , Email:Yixuejie8387@163.com

Advances in biological and pathological functions of long-chain acyl-CoA synthetase 4

WAN Gen-Meng¹ , YANG Yang^1,2 , LI Meng-Huan¹ , MA Qian-He³ , YI Xue-Jie^1,4,*

¹College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China ²School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China ³School of Physical Education, Liaoning Normal University, Dalian 116029, China ⁴Sports Social Science Research Center, Shenyang Sport University, Shenyang110102, China

Abstract:

ACSL4 (long-chain acyl-CoA synthetase 4) is an important catalase for polyunsaturated fatty acid
(PUFA) metabolism and is widely found in tissues where steroids are synthesized. Previous studies on ACSL4 mostly focused on its roles in regulating lipid metabolism. However, it has shown recently that ACSL4 is closely related to various biological processes, such as insulin secretion, skeletal muscle protein metabolism and inflammatory response of the body, and ACSL4 may regulate the development of cancer, ischemic stroke and acute kidney injury by mediating ferroptosis. In addition, ACSL4 is dysregulated in nonalcoholic fatty liver disease and hepatocellular carcinoma, and promotes hepatocyte proliferation by upregulating mTOR phosphorylation or c-Myc, suggesting that ACSL4 may be a therapeutic target for a variety of diseases. In this paper, we mainly review the newly reported physiological and pathological roles of ACSL4, aiming to provide theoretical basis for related research and treatment of diseases.

Communication Author：YI Xue-Jie , Email:Yixuejie8387@163.com