《生命科学》 2023, 35(7): 883-893

衰老过程中氧化应激和炎症对血睾屏障的损伤作用及机制研究进展

汤骐宾¹ , 何露露¹ , 吴佳楠¹ , 李一航¹ , 陈棉海¹ , 罗紫艺¹ , 黄佩颖¹ , 陆多多¹ , 朱金凤¹ , 杜以宽^2,* , 杨　春^1,*

¹广东医科大学东莞市干细胞与再生组织工程重点实验室，东莞 523808 ²南方医科大学第十附属医院(东莞市人民医院)，东莞 523059

摘　要：

血睾屏障对促进精子发生和维持正常的生精微环境至关重要。随着年龄增长，血睾屏障功能受损并伴有相关连接蛋白表达水平和定位的改变，而氧化应激和炎症是衰老时血睾屏障受损的关键。本文就氧化应激和炎症在睾丸衰老过程中破坏血睾屏障的具体作用机制展开综述。

通讯作者：杜以宽 , Email:duane@smu.edu.cn 杨　春 , Email:yangchunangel@163.com

Research progress on the effects and mechanisms of oxidative stress and inflammation on blood-testis barrier in aging

TANG Qi-Bin¹ , HE Lu-Lu¹ , WU Jia-Nan¹ , LI Yi-Hang¹ , CHEN Mian-Hai¹ , LUO Zi-Yi¹ , HUANG Pei-Ying¹ , LU Duo-Duo¹ , ZHU Jin-Feng¹ , DU Yi-Kuan^2,* , YANG Chun^1,*

¹Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, Guangdong Medical University, Dongguan 523808, China ²The Tenth Affiliated Hospital of Southern Medical University, Dongguan, 523059, China

Abstract:

The blood-testis barrier is essential to promote spermatogenesis and maintain an optimum microenvironment for spermatogenesis. In the aging process, the blood-testis barrier function is damaged and accompanied by changes in the expression level and localization of cell junction proteins. Oxidative stress and inflammation are the key factors for the damage of the blood-testis barrier during aging. In this review, we describe the specific mechanisms of oxidative stress and inflammation disrupting the blood-testis barrier during testicular aging.

Communication Author：DU Yi-Kuan , Email:duane@smu.edu.cn YANG Chun , Email:yangchunangel@163.com