《生命科学》 2023, 35(7): 870-875

PM_2.5致心血管系统损伤及机制研究进展

王　涵¹ , 劳文艳¹ , 李松霖¹ , 秦　菲^1,* , 吴国浩^2,*

¹北京联合大学生物化学工程学院，北京 100023 ²北京同仁堂股份有限公司科学研究所，北京 100011

摘　要：

细颗粒物(particulate matter, PM_2.5) 是一种严重的环境污染物质。它对机体多系统都有不良影响，而心血管系统是其主要目标，因此PM_2.5 暴露对心血管系统的影响越来越受到人们的关注。许多研究表明PM_2.5 与心血管疾病(cardiovascular disease, CVD) 的发病率和死亡率之间具有明确的因果关系。PM_2.5 通过氧化应激、炎症、线粒体损伤、细胞凋亡等机制对心血管系统造成损伤，成为CVD 的主要死亡危险因素。本文从流行病学、动物、细胞水平的角度总结了PM_2.5 诱导CVD 机制的研究现状，为更好地了解心血管致病机理，提高公众对PM_2.5 对CVD 危害的认识，为预防、管理、治疗PM_2.5 引起的CVD 提供科学依据。

通讯作者：秦　菲 , Email:qinfei@buu.edu.cn 吴国浩 , Email:gegeorge_ng@163.com

Research progress on cardiovascular system injury caused by PM_2.5 and related mechanisms

WANG Han¹ , LAO Wen-Yan¹ , LI Song-Lin¹ , QIN Fei^1,* , WU Guo-Hao^2,*

¹College of Biochemical Engineering, Beijing Union University, Beijing 100023, China ²Scientific Research Institute of Beijing Tongrentang Co., Ltd, Beijing 100011, China

Abstract:

Cardiovascular system is the main target of fine particulate matter (PM_2.5), a serious environmental contaminant, which has adverse health effects on multiple body systems. Therefore the influence of PM_2.5 exposure to cardiovascular system has drawn more and more attention. A unequivocal link between PM_2.5 and morbidity and mortality of cardiovascular diseases (CVD) has been proved by a number of studies. Cardiovascular system injury was induced by PM_2.5 through mechanisms of oxidative stress, inflammation, mitochondrial dysfunction and cell apoptosis, etc., thus PM_2.5 has become the main risk factor for CVD death. Current researches on mechanisms of PM_2.5-induced CVD were summarized from the perspectives of human epidemiology, animal and cell, to improve the public awareness to CVD induced by PM_2.5 and provide a scientific basis for the prevention, management and treatment of CVD caused by PM_2.5.

Communication Author：QIN Fei , Email:qinfei@buu.edu.cn WU Guo-Hao , Email:gegeorge_ng@163.com