《生命科学》 2023, 35(7): 849-860

RNA甲基化对小鼠早期胚胎发育过程的影响

汪　璐¹ , 颜景斌^1,2,*

¹上海市儿童医院，上海医学遗传学研究所，上海交通大学医学院，上海 200040 ²国家卫健委胚胎分子生物学重点实验室，上海市胚胎与生殖工程重点实验室，上海 200040

摘　要：

近年来，研究发现RNA 修饰可调控不同的生理过程，特别是在早期胚胎发育过程中起重要的作用。RNA 的甲基化是哺乳动物细胞中存在的最普遍的RNA 修饰之一，也是一种重要的RNA 转录和转录后水平的调控机制。本综述旨在总结N⁶- 甲基腺苷(N⁶-methyladenosine, m⁶A) 和5- 甲基胞嘧啶(5-methylcytosine, m⁵C) 在小鼠早期胚胎发育过程中的关键作用，为更好地理解表观转录组调控与小鼠胚胎发育之间的整体联系奠定基础。

通讯作者：颜景斌 , Email:yanjb@shchildren.com.cn

Effect of RNA methylation on early embryo development in mice

WANG Lu¹ , YAN Jing-Bin^1,2,*

¹Shanghai Children’s Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, Shanghai 200040, China ²NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai 200040, China

Abstract:

Recently, RNA modifications have emerged as an important regulator of different physiological
processes, especially play an important role in early embryonic development. Among them, RNA methylation is one of the most ubiquitous RNA modifications in mammalian cells as well as an important regulatory mechanism at both transcriptional and post-transcriptional levels. Therefore, this review is aiming at summarizing the key roles of N⁶-methyladenosine (m⁶A) and 5-methylcytosine (m⁵C) in mouse early embryonic development, so as to lay the foundation for better understanding the overall link between epigenetic transcriptome regulation and mouse embryonic development.

Communication Author：YAN Jing-Bin , Email:yanjb@shchildren.com.cn