《生命科学》 2023, 35(6): 807-815

NLRP3炎症小体在脂肪组织纤维化中的作用及运动干预研究进展

王伟庆 , 柯志飞 , 周　越^*

北京体育大学运动人体科学学院，北京 100084

摘　要：

脂肪组织纤维化是指白色脂肪组织细胞外基质的过度沉积，是代谢功能障碍的重要诱因，探究其发生机理对代谢相关疾病的防治意义重大。研究表明，NLRP3 炎症小体与脂肪组织纤维化关联密切，但其机制尚未完全厘清。作为一种防治慢病的有效策略，运动可通过抑制NLRP3 炎症小体活化减轻炎症反应，从而缓解炎症相关疾病的发生与发展。本文就NLRP3 炎症小体的生物学特性以及与脂肪组织纤维化的关系进行归纳梳理，总结分析运动通过NLRP3 炎症小体调节脂肪组织纤维化的可能机理，以期为脂肪组织炎症相关疾病的防治提供理论参考依据。

通讯作者：周　越 , Email:zhouy@bsu.edu.cn

Research progress on the role of NLRP3 inflammasome in adipose tissue fibrosis and exercise intervention

WANG Wei-Qing , KE Zhi-Fei , ZHOU Yue^*

College of Exercise and Human Sciences, Beijing Sport University, Beijing 100084, China

Abstract:

Adipose tissue fibrosis refers to the excessive deposition of extracellular matrix in white adipose tissue, which is an important cause of metabolic dysfunction. Exploring the mechanism of adipose tissue fibrosis is of great significance for the prevention and treatment of metabolic diseases. Studies have shown that NLRP3 inflammasome is closely associated with adipose tissue fibrosis, but its mechanism is not fully understood. As an effective strategy for the prevention and treatment of chronic diseases, exercise can reduce the inflammatory response by inhibiting the activation of NLRP3 inflammasome, thus alleviating the occurrence and development of inflammation-related diseases. In this review, we summarize the biological characteristics of NLRP3 inflammasome and its relationship with adipose tissue fibrosis, and propose the possible mechanism of exercise regulating adipose tissue fibrosis through NLRP3 inflammasome, in order to provide theoretical reference for the prevention and treatment of adipose tissue inflammation-related diseases.

Communication Author：ZHOU Yue , Email:zhouy@bsu.edu.cn