《生命科学》 2023, 35(6): 799-806

HMGB1在角膜损伤和修复中的作用研究进展

王志浩^1,2 , 郭　龙^1,2 , 王培³ , 李建基^1,2 , 王　亨^1,2,*

¹扬州大学兽医学院，江苏省动物重要疫病与人兽共患病防控协同创新中心，扬州 225009 ²农业与农产品安全教育部国际联合研究实验室，江苏高校动物重要疫病和重要人兽共患病防控技 术国际合作联合实验室，扬州 225009 ³南京中医药大学第三临床医学院，南京 210028

摘　要：

角膜是眼部抵御外来病原微生物侵入的重要屏障，其完整性与眼部健康密切相关。角膜发生损伤后，其自身会进行修复和重新上皮化，该过程常伴随炎症反应及炎症介质的释放。适度的炎症反应可促进损伤修复，而过度炎症反应会伴有大量炎症介质的释放，加剧角膜损伤。高迁移率族蛋白1 (high mobility group box 1, HMGB1) 是参与角膜组织损伤和修复过程的常见炎症介质之一，过度表达的HMGB1 可加剧角膜修复过程中的瘢痕化，导致角膜透明度降低，对疾病的转归产生负面影响。因此，干扰HMGB1 有望成为治疗角膜损伤的新方式。本文从HMGB1 的结构与功能、HMGB1 在角膜损伤及修复中的作用、HMGB1 的调控及其在角膜疾病中的应用三个方面进行回顾和总结。

通讯作者：王　亨 , Email:sdaulellow@163.com

Review on the function of HMGB1 in the process of corneal wound and recovery

WANG Zhi-Hao^1,2 , GUO Long^1,2 , WANG Pei-Li³ , LI Jian-Ji^1,2 , WANG Heng^1,2,*

¹Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, ²Joint International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education, Joint International Research Laboratory of Important Animal Infectious Diseases and Zoonoses of Jiangsu Higher Education Institutions, Yangzhou 225009, China ³The Third School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China

Abstract:

The cornea is the important barrier of the eye against the invasion of pathogenic microorganisms, and its integrity is related to the health of the eye. When the cornea is injured, it could repair and epithelialize by itself. The process is often accompanied by an inflammatory response and the release of inflammatory production. A moderate inflammatory response could promote recovery of the wound, while an excessive inflammatory response released lots of inflammatory cytokines, which could exacerbate the wound. High mobility group box 1 (HMGB1), is one of the common inflammatory mediators, which is involved in the pathophysiological process of corneal injury and recovery. Overexpression of HMGB1 protein could promote scar formation during the process of corneal recovery, which also reduced the transparency of the cornea and influenced the outcome of the disease. Therefore, regulating HMGB1 would be a new way to treat corneal wounds. The article reviewed the structure and function of HMGB1 protein, the function of HMGB1 in the process of corneal wound recovery, and the application of and the regulation of HMGB1 in corneal diseases.

Communication Author：WANG Heng , Email:sdaulellow@163.com