《生命科学》 2023, 35(6): 790-798

CircRNA在动物脂质代谢中的调控作用

户春丽 , 马燕芬 , 马　云^*

宁夏大学动物科技学院，宁夏回族自治区反刍动物分子细胞育种重点实验室，银川 750021

摘　要：

脂质代谢具有复杂的生理过程，受激素、转录因子、酶和非编码RNA 等多种因素影响，其中遗传是主要因素之一。环状RNA (circular RNA, circRNA) 是存在于真核生物中的共价闭合的环形非编码RNA，具有组织特异性、保守性和稳定性。近年来，circRNA 在脂肪生成和发育中的分子调控机制被广泛研究。本文概述了脂肪的分类、功能及其生成的调控机制，并重点综述circRNA 对脂质代谢的调控，尤其是circOgdh 和circHIPK3 等标志性circRNA 在动物脂肪沉积调控中的作用，以期为后续研究提供参考。

通讯作者：马　云 , Email:mayun_666@126.com

Regulatory effects of circRNA on lipid metabolism in animals

HU Chun-Li , MA Yan-Fen , MA Yun^*

Key Laboratory of Molecular Cell Breeding of Ruminants in Ningxia Hui Autonomous Region, College of Animal Science and Technology, Ningxia University, Yinchuan 750021, China

Abstract:

Lipid metabolism is a complex physiological process, which is affected by a variety of factors, such as hormones, transcription factors, enzymes and non-coding RNAs, and inheritance is one of the main factors. CircRNAs (circular RNAs) are covalently closed circular non-coding RNAs existing in eukaryotes, which are tissue specific, conservative and stable. In recent years, the regulatory roles of circRNAs in lipogenesis and development are widely studied. In this paper, the classification, function of fat and the regulatory mechanism of its production were summarized, focusing on the regulation of lipid metabolism by circRNAs, especially circOgdh and circHIPK3 in the regulation of animal adipose deposition, in order to provide reference for the subsequent research.

Communication Author：MA Yun , Email:mayun_666@126.com