《生命科学》 2023, 35(6): 733-742

SIgA与哺乳动物肠道菌群互作的研究进展

吴元霞^1,2 , 孙　静^2,3 , 葛良鹏^2,3 , 李周权^1,* , 张进威^2,3,*

¹西南大学动物科学技术学院生物饲料与分子营养实验室，重庆 400715 ²重庆市畜牧科学院，重庆 402460 ³农业部养猪科学重点实验室，重庆 402460

摘　要：

肠道微生物伴随宿主一生，对宿主的消化吸收以及肠道健康产生巨大影响。肠道微生物的动态平衡维护宿主稳态，而肠道微生物失调会引起宿主肠道相关疾病。分泌型免疫球蛋白A (secretory IgA, SIgA)作用于肠道微生物，影响其组成、代谢和定植，调节肠道微生物的动态平衡。SIgA 与肠道微生物的互作维持了肠道微生物与宿主的互利共生。然而，目前对于SIgA 与肠道微生物的互作机制还缺乏系统解析。本文从SIgA 的产生机制、肠道微生物对SIgA 的诱导以及降解作用、SIgA 对肠道微生物的组成及定植的影响进行阐述，主要综述SIgA 与肠道微生物的相互作用，以期为肠道微生物相关疾病的机理阐释及检测治疗提供理论依据。

通讯作者：李周权 , Email:marcli@126.com 张进威 , Email:jinweizhang50@163.com

Progress in the interaction between SIgA and mammalian gut flora

WU Yuan-Xia^1,2 , SUN Jing^2,3 , GE Liang-Peng^2,3 , LI Zhou-Quan^1,* , ZHANG Jin-Wei^2,3,*

¹Key Laboratory for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China ²Chongqing Academy of Animal Sciences, Chongqing 402460, China ³Key Laboratory of Pig Raising Science, Ministry of Agriculture, Chongqing 402460, China

Abstract:

Gut microbiota accompanies the host's life and has a huge impact on the host's digestion, absorption and intestinal health. The dynamic balance of gut microbiota maintains host homeostasis, while gut microbiota dysbiosis causes host gut-related diseases. Secretory immunoglobulin A (SIgA) acts on gut microbiota, affecting their composition, metabolism, and colonization, and regulating the homeostasis of gut microbiota. The interaction between SIgA and gut microbiota maintains the mutual symbiosis between gut microbiota and the host. However, there is still a lack of systematic analysis of the interaction mechanism between SIgA and gut microbiota. In this review, we focus on the production mechanism of SIgA, the induction and degradation of SIgA, the effects of SIgA on the composition of intestinal microbiota and colonization, and mainly review the interaction between SIgA and intestinal microbiota to provide a theoretical basis for the mechanism interpretation and detection and treatment of intestinal microbiota-related diseases.

Communication Author：LI Zhou-Quan , Email:marcli@126.com ZHANG Jin-Wei , Email:jinweizhang50@163.com