《生命科学》 2023, 35(6): 724-732

从氧化应激视角探讨物质成瘾

韩　爽^1,2,3 , 张昌林^1,2,4 , 陈　越^1,2 , 李自成^1,2,*

¹三峡大学基础医学院机能学系，宜昌 443002 ²三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002 ³三峡大学人民医院/宜昌市第一人民医院，宜昌 443002 ⁴宜昌市中心人民医院，三峡大学第一临床医学院，宜昌 443003

摘　要：

物质成瘾是一种慢性复发性神经适应障碍，在全球范围内物质成瘾者基数大，对当今世界的经济及社会发展造成极大危害。物质成瘾涉及多个脑区、信号转导途径、转运体及受体，是一个相对复杂的过程。氧化应激是自由基引起的氧化和抗氧化系统失衡的负面反应。有证据表明，成瘾性物质诱导大脑发生明显的氧化应激反应，可能为物质成瘾的分子机制研究提供新的线索。本文讨论了在成瘾性物质作用下大脑发生的氧化应激反应以及氧化应激反应对动物行为的影响，并进一步探讨其分子生物学机制。

通讯作者：李自成 , Email:zichengli@ctgu.edu.cn

Investigating substance addiction from the perspective of oxidative stress

HAN Shuang^1,2,3 , ZHANG Chang-Lin^1,2,4 , CHEN Yue^1,2 , LI Zi-Cheng^1,2,*

¹Department of Functional Sciences, College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, China ²Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China ³People's Hospital of Three Gorges University/The First People's Hospital of Yichang, Yichang 443002, China ⁴The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China

Abstract:

Substance addiction is a chronic and relapsing neuroadaptive disorder. There are a large number of substance addicts worldwide, which has caused great harm to the economic and social development. Substance addiction is a complex process involving multiple brain regions, signal transduction pathways, transporters and receptors. Oxidative stress is a negative consequence of the imbalance of oxidative and antioxidant systems caused by free radicals. There is evidence suggesting that addictive substances induce a pronounced oxidative stress response in the brain, which may provide new clues to study the molecular mechanisms of substance addiction. In this review, we discuss the neurobiological consequences of oxidative stress in the brain after addictive substance use, as well as the effects of oxidative stress on animal behavior, and further explore the molecular biological mechanisms.

Communication Author：LI Zi-Cheng , Email:zichengli@ctgu.edu.cn