《生命科学》 2023, 35(6): 714-723

m⁶A甲基转移酶METTL3在胚胎发育中的作用研究进展

王璇璇^1,2,3,4 , 韩兵社^1,2,3,4,* , 张俊芳^1,2,3,4

¹上海海洋大学水产种质资源发掘与利用教育部重点实验室，上海 201306 ²上海海洋大学， 水产科学国家级实验教学示范中心，上海 201306 ³上海海洋大学，科技部海洋生物科学国际联 合研究中心，上海 201306 ⁴临港新片区海洋生物医药科技创新型平台，上海 201306

摘　要：

胚胎发育调控机制是一个非常重要的生物学基础问题，而其中的表观遗传学机制成为最近的研究热点。研究发现，甲基转移酶样3 (methyltransferase-like 3, METTL3) 催化产生的m⁶A 修饰在卵母细胞成熟、母源- 合子转化、胚胎干细胞命运调控以及血管生成等胚胎发育过程中发挥重要作用。同时，靶向METTL3 的化合物也不断被发现与合成，有望应用于m⁶A 相关疾病的靶向治疗。本文就METTL3 的结构、催化机制、调控机制、在RNA 代谢和胚胎发育中的作用以及METTL3 靶向化合物进行介绍。

通讯作者：韩兵社 , Email:bs-han@shou.edu.cn

Research progress on the role of m⁶A methyltransferase METTL3 in embryonic development

WANG Xuan-Xuan^1,2,3,4 , HAN Bing-She^1,2,3,4,* , ZHANG Jun-Fang^1,2,3,4

¹Key Laboratory of Ministry of Education for Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Shanghai 201306, China ²National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China ³International Research Center of Ministry of Science and Technology for Marine Biosciences, Shanghai Ocean University, Shanghai 201306, China ⁴Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China

Abstract:

The regulatory mechanism of embryonic development is a very important fundamental question in biology, and the role of epigenetic modification has become a recent research hotspot. Accumulating studies showed that m⁶A modification produced by methyltransferase-like 3 (METTL3) plays important roles during embryonic development such as oocyte maturation, maternal-to-zygotic transition, embryonic stem cell fate regulation and angiogenesis. Meanwhile, compounds targeting METTL3 have also been continuously discovered and synthesized, which are expected for targeting m⁶A-related diseases. In this paper, the structure, catalytic mechanism and regulatory mechanism of METTL3 are reviewed, its function in RNA metabolism and embryonic development, and METTL3-targeted compounds are also introduced.

Communication Author：HAN Bing-She , Email:bs-han@shou.edu.cn