《生命科学》 2023, 35(5): 689-700

胰腺微环境外泌体miRNA参与胰腺炎症和纤维化的发病机制研究进展

唐山淦¹ , 许小凡¹ , 段丽芳¹ , 张　红^1,2,*

¹陕西中医药大学，咸阳 712046 ²陕西省免疫炎症相关疾病中医药防治国际联合研究中心，咸阳 712046

摘　要：

慢性胰腺炎(chronic pancreatitis, CP) 发病率逐年上升，目前尚无明确根治性治疗方法且后期有进展为胰腺癌的风险。CP 的典型病理学特征是胰腺慢性炎症和纤维化，CP 进展与胰腺微环境中三种主要细胞( 腺泡细胞、巨噬细胞以及胰腺星状细胞) 间的相互作用密切相关，然而它们具体是如何进行细胞间联系的目前尚不清楚。新近研究表明外泌体作为细胞间重要的通讯介质，其携带的miRNA 可通过调控主要细胞内基因表达和信号通路等影响CP 的发生发展。本文围绕胰腺微环境中外泌体来源miRNA 与三种主要细胞相互作用的机制，对其最新研究进展进行归纳和总结分析，以期为CP 发病机制的深入认识提供参考。

通讯作者：张　红 , Email:zhangh1227@163.com

The research advance on the mechanism of the exosomal miRNA in pancreatic microenvironment in the  pathogenesis of pancreatic inflammation and fibrosis

TANG Shan-Gan¹ , XU Xiao-Fan¹ , DUAN Li-Fang¹ , ZHANG Hong^1,2,*

¹Shaanxi University of Chinese Medicine, Xianyang 712046, China ²Shaanxi Province International Joint Research Center for the Prevention and Treatment of Immune and Inflammation-related Diseases in Traditional Chinese Medicine, Xianyang 712046, China

Abstract:

The incidence of chronic pancreatitis (CP) is increasing year by year, and there is no curative treatment and a risk of developing pancreatic cancer in the later stage. The typical pathological features of CP are chronic inflammation and fibrosis of the pancreas. The  development of CP is closely related to the three main intercellular interactions of acinar cell, macrophage and pancreatic stellate cell in the pancreatic  microenvironment. But how exactly do they communicate between each other? Recent studies have shown that exosomes are important communication media between cells, and the miRNA they carry can affect the occurrence and development of CP by regulating intracellular gene expression and signaling pathways of the three major cells. In this paper, focusing on the mechanism of interaction between exosome-derived miRNA and the three main cells in the pancreatic microenvironment, the latest research progress was summarized and analyzed, in order to provide a reference for the in-depth understanding of the pathogenesis of CP.

Communication Author：ZHANG Hong , Email:zhangh1227@163.com