《生命科学》 2023, 35(5): 654-662

肠道运动疾病与情绪异常共病发生的TRP通道机制

何　法^1,2,3,4 , 刘　畅^1,2,3,4 , 吴艳艳^1,2,3,4 , 刘　霞^1,2,3,4 , 姜　鸣^1,2,3,4 , 杨清湖^1,2,3,4 , 杨　亮^1,2,3,4,* , 白占涛^1,2,3,4,*

¹延安大学生命科学学院/多肽资源药物研究中心，延安 716000 ²陕西省区域生物资源 保育与利用工程技术研究中心，延安 716000 ³延安市多肽资源药物工程技术研究中心， 延安 716000 ⁴延安市神经肿瘤免疫与干细胞重点实验室，延安 716000

摘　要：

肠道运动疾病与情绪异常共病是全球关注的健康问题。研究表明，瞬时受体电位(transient receptor potential, TRP) 通道可调节肠道运动、菌群和稳态，并参与情绪的发生发展，其系统机制有待研究阐明。本文综合肠道运动障碍相关神经递质、激素、Ca2+、肠道菌群与TRP 通道的生理病理变化，相较于情绪异常相关的肠道运动与TRP 通道，提出肠道运动疾病与情绪异常共病发生的TRP 通道机制，以期为脑- 肠与肠-脑系统稳态调控相关疾病的诊疗提供新思路。

通讯作者：杨　亮 , Email:lyang@yau.edu.cn 白占涛 , Email:ztbai@yau.edu.cn

TRP channel mechanisms in the co-morbid occurrence of gut motility disorders and emotional abnormalities

HE Fa^1,2,3,4 , LIU Chang^1,2,3,4 , WU Yan-Yan^1,2,3,4 , LIU Xia^1,2,3,4 , JIANG Ming^1,2,3,4 , YANG Qing-Hu^1,2,3,4 , YANG Liang^1,2,3,4,* , BAI Zhan-Tao^1,2,3,4,*

¹School of Life Science & Research Center for Natural Peptide Drugs, Yan’an University, Yan’an 716000, China ²Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yan’an 716000, China ³Yan’an Engineering & Technological Research Center for Resource Peptide Drugs, Yan’an 716000, China ⁴Yan’an Key Laboratory for Neural Immuno-Tumor and Stem Cell, Yan’an 716000, China

Abstract:

Co-morbidity of gut motility disorders with mood  abnormalities is a global health concern. Studies have shown that transient receptor potential (TRP) channels  regulate intestinal motility, flora and homeostasis, and are
involved in the development of mood, with systemic  mechanisms to be elucidated. This paper integrates the
physiopathological changes of neurotransmitters,  hormones, Ca2+, intestinal flora and TRP channels related to intestinal motility disorders, and proposes a TRP channel mechanism for the co-morbidity of intestinal motility disorders and mood disorders, compared with the intestinal motility and TRP channels related to mood disorders, in order to provide new ideas for the diagnosis and treatment of homeostatic regulation of brain-gut and gut-brain systems.

Communication Author：YANG Liang , Email:lyang@yau.edu.cn BAI Zhan-Tao , Email:ztbai@yau.edu.cn