《生命科学》 2023, 35(5): 629-641

细胞融合在人类疾病病理与医学应用中的研究进展

王琳蓉¹ , 董彩华² , 程乐平^1,2,3,*

¹广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心，广西再生医学重点实验室，南宁 530021 ²广西医科大学基础医学院，神经科学研究所，广西脑科学研究重点实验室，广西壮族自治区卫生健康委员会脑功能与脑疾病基础研究重点实验室(广西医科大学)，南宁 530021 ³长寿与老年相关疾病教育部重点实验室，南宁 530021

摘　要：

细胞融合包括细胞识别和黏附、融合孔开放以及胞质混合等基本步骤，它参与人类的许多生理病理过程。细胞融合为受精卵、胎盘、骨骼肌、破骨细胞等组织细胞正常发育所必需。同时，细胞融合在癌细胞的产生、恶性转移以及病毒入侵等人类重大疾病的发生发展中发挥了重要作用，这严重威胁人类的生命健康。本文围绕细胞融合参与的生理、病理过程，借助相关研究的最新进展，揭示细胞融合在人类疾病病理中的重要作用，进而提出了阻断细胞融合以减缓病毒入侵人体细胞以及肿瘤细胞的产生与扩散的治疗新策略；进一步探讨了细胞融合在干细胞介导的组织再生以及细胞重编程中的潜在作用。这将深化人们对细胞融合在相关疾病病理中作用的认识，并大力推进细胞融合分子的临床应用进程。

通讯作者：程乐平 , Email:lpcheng@gxmu.edu.cn

Research advances on the role of cell fusion in human pathology and its medical application

WANG Lin-Rong¹ , DONG Cai-Hua² , CHENG Le-Ping^1,2,3,*

¹Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine, Nanning 530021, China ²Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China ³Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Nanning 530021, China

Abstract:

Cell fusion comprises three basic steps of cell recognition and adhesion, the opening of fusion pore and cytoplasmic mixing, and it participates in a number of physiological and pathological processes. Cell fusion is indispensable for the development of fertilized eggs, the placenta, skeletal muscle, and osteoclast cells. At the meanwhile, cell fusion plays critical roles in the  occurrence and metastasis of malignant tumor cells, and the viral infection, which are seriously threatening the lives and health of mankind. Focusing on the processes in which cell fusion is involved, the important functions of cell fusion underlying human pathology are summarized with the latest advances and novel therapeutic strategies for slowing down the viral invasion, and the generation and spread of cancer cells are proposed. Furthermore, the potential applications of cell fusion in stem cell-mediated tissue regeneration and cell reprogramming are  discussed. This will deepen our understanding on the roles cell fusion plays in related human diseases, and ultimately will facilitate the clinical application of cell fusion.

Communication Author：CHENG Le-Ping , Email:lpcheng@gxmu.edu.cn