《生命科学》 2023, 35(5): 601-608

亚精胺对EIF5A的hypusine修饰的生理病理功能研究进展

段兵兵 , 王方珂 , 周远飞^*

华中农业大学动物科学技术学院/动物医学院，武汉 430070

摘　要：

亚精胺是生物体内普遍存在的生物活性小分子—— 多胺家族的一员，具有多种重要的生物学功能，其中最特别的是参与真核翻译起始因子5A (eukaryotic translation initiation factor 5A, EIF5A) 的活化，对EIF5A上一个特定赖氨酸残基进行修饰，称为hypusine 修饰。目前关于亚精胺通过EIF5A 的hypusine 修饰对相关生物事件影响的研究备受关注。该文总结了在人生理病理方面亚精胺相关的报道，重点关注亚精胺通过EIF5A的hypusine 修饰影响生理病理功能的研究进展，以期为亚精胺在医学和营养健康方面的应用研究提供参考。

通讯作者：周远飞 , Email:zhouyuanfei@mail.hzau.edu.cn

Advances in the study of spermidine via hypusine modification of EIF5A in physiopathology

DUAN Bing-Bing , WANG Fang-Ke , ZHOU Yuan-Fei^*

College of Animal Sciences & Technology/College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China

Abstract:

Spermidine is a member of the polyamine family, a family of biologically active small molecules  prevalent in living organisms, and has a variety of important biological functions. The most special one of these functions is its involvement in the activation of eukaryotic translation initiation factor 5A (EIF5A) by modifying a specific lysine residue on the EIF5A molecule, called hypusine modifying effect. Much attention is currently being paid to the study of the effect of spermidine on related biological events through the hypusine modification of EIF5A. This paper summarizes the reports related to spermidine in human physiopathology, focusing on the research progress of spermidine on physiopathology through hypusine modification of EIF5A, in order to provide a reference for research on the application of spermidine in medicine   and nutritional health.

Communication Author：ZHOU Yuan-Fei , Email:zhouyuanfei@mail.hzau.edu.cn