《生命科学》 2023, 35(5): 583-591

HDACs去乙酰化酶非依赖性作用在疾病中的研究进展

张艺蓉 , 陈力方 , 王维蓉^*

西安交通大学医学部基础医学院，西安 710061

摘　要：

组蛋白去乙酰化酶(histone deacetylases, HDACs) 参与并调节众多生理病理进程，在机体内发挥重要作用。近年来越来越多的文献报道HDACs 家族成员具有独立于去乙酰化酶活性的作用。本文围绕四类HDACs，综述了其最新的去乙酰化酶非依赖性调控作用，主要介绍它们的结构、生物学功能以及和疾病的
关系，旨在从其结构特点揭示不同的生物学功能，进而探究对疾病发生发展的影响。去乙酰化酶非依赖性作用的研究不仅有助于对HDACs 在疾病发生发展中的作用及机制的全新理解，也为以HDACs 功能为靶点的新药研发提供新的思路。

通讯作者：王维蓉 , Email:szb2013072@xjtu.edu.cn

Research progress on the deacetylase-independent effect of HDACs in diseases

ZHANG Yi-Rong , CHEN Li-Fang , WANG Wei-Rong^*

School of Basic Medicine, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China

Abstract:

Histone deacetylases (HDACs) participate in many physiological and pathological processes, and play an important role in human body. Recently, accumulating studies demonstrated the role of HDACs  deacetylaseindependent activity in diseases. This paper reviews the latest deacetylase-independent effects of class I, II, III and IV HDACs, and mainly introduces their structure, biological function and relationships with diseases. It aims to reveal different biological functions of HDACs from structural characteristics, and then explore their impacts on the occurrence and development of diseases. It not only facilitates the comprehensive understanding of the role and related mechanism of HDACs in the progress of diseases, but also provides new ideas for drug discovery targeting HDAC functions.

Communication Author：WANG Wei-Rong , Email:szb2013072@xjtu.edu.cn