《生命科学》 2023, 35(5): 569-575

Pgp3生物学特性与致病机制研究进展

方春霞¹ , 周　辉² , 李忠玉^1,*

¹南华大学衡阳医学院病原生物学研究所/特殊病原体防控湖南省重点实验室，衡阳 421001 ²湖南中医药大学第一附属医院，长沙 410021

摘　要：

衣原体具有广泛的致病谱，能够引起多种疾病，而分泌性蛋白在衣原体致病过程中发挥了重要的作用。Pgp3 (plasmid gene protein 3) 是由衣原体质粒基因编码的一种主要定位于宿主细胞质的分泌性蛋白，具有调控炎症反应、细胞凋亡、自噬等多种生物学功能。Pgp3 也是一种免疫优势抗原，可用于衣原体疾病的诊断和作为疫苗研制的靶点。全面、深入地研究该蛋白功能将有助于进一步了解衣原体的致病机制，为衣原体感染的诊断和防治提供新的思路。

通讯作者：李忠玉 , Email:lzhy1023@hotmail.com

Research progress on the biological characteristics and pathogenesis of Pgp3

FANG Chun-Xia¹ , ZHOU Hui² , LI Zhong-Yu^1,*

¹Pathogenic Biology Institute ＆ Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang Medical College, University of South China, Hengyang 421001, China ²The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, China

Abstract:

Chlamydia has a wide pathogenic spectrum and can cause a variety of diseases, and secretory proteins play an important role in the pathogenesis of Chlamydia. Pgp3 (plasmid gene protein 3) is a secretory protein encoded by the plasmid gene of Chlamydia. It is mainly located in the host cytoplasm and has a variety of biological functions such as regulating inflammation, apoptosis and autophagy. Pgp3 is also an immunodominant antigen that can be used in the diagnosis of Chlamydia infection and as a target for vaccine development. Comprehensive and in-depth study of the function of this protein will be helpful to further understand the pathogenesis of  Chlamydia, and provide a new idea for the diagnosis and prevention of Chlamydia infection.

Communication Author：LI Zhong-Yu , Email:lzhy1023@hotmail.com