《生命科学》 2023, 35(4): 500-508

胎儿肠道微生物的来源及其对胎儿发育的影响

邹兴愿 , 柳陈坚 , 李晓然^*

昆明理工大学生命科学与技术学院，昆明 650500

摘　要：

肠道微生物组在调节人体新陈代谢、免疫功能和行为方面至关重要，并且在胎儿时期就已开始建立。母体各部位的微生物及其代谢物通过血液及阴道上行传播至胎儿组织，并影响胎儿的神经系统发育以及免疫系统的建立和启动。胎儿时期微生物的存在、发展及变化等过程对胎儿发育以及胎儿分娩后的健康状态具有深刻意义。本文着重介绍了胎儿时期肠道微生物的初始定植期、来源途径及其对胎儿发育产生的影响，以此更好地理解胎儿时期微生物与胎儿之间的相互作用及其与长期健康的关联，为改善婴儿短期和长期健康的相关研究提供参考。

通讯作者：李晓然 , Email:starkeyran@163.com

The origin of fetal intestinal microbes and their effects on fetal development

ZOU Xing-Yuan , LIU Chen-Jian , LI Xiao-Ran^*

Faculty of Life Science and Technology, Kunming University of Science and Technology, kunming 650501, China

Abstract:

Intestinal microbiome plays a crucial role in regulating human metabolism, immune function and
behavior, and has been established in the fetal period. Microbes and their metabolites in various parts of the mother's body are transmitted upward through the blood and vagina to the fetal tissues, and affect the neural development of the fetus and the establishment and start of the immune system. The processes of the existence, development and change of microorganisms during the fetal period have profound significance for the fetal development and the health status of the fetus after delivery. This article focuses on the initial colonization period, source route of intestinal microorganisms in the fetal period and their impact on fetal development, so as to better understand the interaction between microorganisms in the fetal period and the fetus and its relationship with long-term health, and provide reference for relevant research on improving short-term and long-term health of infants.

Communication Author：LI Xiao-Ran , Email:starkeyran@163.com