《生命科学》 2023, 35(4): 493-499

转录调节因子KLF9的研究进展

卢光振¹ , 任文琦¹ , 张龙玉¹ , 崔安芳^2,*

¹济宁医学院临床医学院，济宁 272067 ²济宁医学院基础医学院，济宁 272067

摘　要：

KLF9 是锌指蛋白Krüppel 样转录因子(Krüppel-like factors, KLFs) 家族的重要成员，通过C 端的3 个C2H2 锌指蛋白结构，结合到靶基因启动子区富含GC 的区域，调节靶基因的转录，从而参与调节细胞增殖、分化、凋亡和组织器官发育等多个生理过程。本文详细梳理了KLF9 在机体代谢、氧化应激、肿瘤的发生发展等多个病理/ 生理过程中的作用，对近年来发表的KLF9 相关文献做一简要概述，为深入解析KLF9 的生理功能及其作用机制提供参考。

通讯作者：崔安芳 , Email:caf911@126.com

Recent progress of transcription factor KLF9

LU Guang-Zhen¹ , REN Wen-Qi¹ , ZHANG Long-Yu¹ , CUI An-Fang^2,*

¹College of Clinical Medicine, Jining Medical University, Jining 272067, China ²College of Basic Medicine, Jining Medical University, Jining 272067, China

Abstract:

As a member of the Krüppel-like factors (KLFs) transcription factor family, KLF9 regulates the
transcriptions of target genes by 3 C2H2 zinc finger motifs, binding to the GC rich region of the target promoters. KLF9 plays important roles in a variety of biological and cellular processes, including cell proliferation, differentiation, apoptosis, and development of tissues and organs. This review summarizes the roles of KLF9 in diverse pathological/physiological processes, including metabolism, oxidative stress and tumorigenesis. Collectively, this review provides a reference for in-depth analysis of the physiological functions and the underlying mechanisms of KLF9.

Communication Author：CUI An-Fang , Email:caf911@126.com