《生命科学》 2023, 35(4): 486-492

间充质干细胞衰老基础的研究进展

周晓宇^1,2 , 王维莉¹ , 高力扬^1,3,*

¹宁夏大学西部特色生物资源保护与利用教育部重点实验室，银川 750021 ²中科宝承生 物医学科技有限公司，银川 750000 ³宁夏大学生命科学学院，银川 750021

摘　要：

间充质干细胞(mesenchymal stem cells, MSCs) 是再生医学领域和组织工程领域研究应用最广泛的成体干细胞。MSCs 不仅随着机体的衰老而衰老，而且 MSCs 的衰老也被认为是引起机体衰老的主要原因，是许多衰老相关退行性疾病的重要诱因。干细胞治疗的发展为衰老相关疾病的治疗带来了新的方向，然而体外扩增过程中供体细胞容易出现衰老，影响治疗效果，制约临床发展与应用。因此，该文针对MSCs 衰老基础研究进行综述，为加快MSCs 临床转化提供参考。

通讯作者：高力扬 , Email:pandarun@nxu.edu.cn

Advances in basic research on senescence of mesenchymal stem cells

ZHOU Xiao-Yu^1,2 , WANG Wei-Li¹ , GAO Li-Yang^1,3,*

¹Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan 750021, China ²ZKBC Biomedical Technology CO., LTD., Yinchuan 750000, China ³College of Life Sciences, Ningxia University, Yinchuan 750021, China

Abstract:

Mesenchymal stem cells (MSCs) are widely used in regenerative medicine and tissue engineering. Senescence of MSCs is closely related to the aging of the body and many aging-related degenerative diseases. The development of stem cell therapy has brought a new direction for the treatment of aging-related diseases. However, donor cells are prone to senescence after multiple passages in vitro, which affects the therapeutic effect and restricts clinical development and application. Therefore, the basic studies on senescence of MSCs are reviewed to provide reference for accelerating the clinical transformation of MSCs.

Communication Author：GAO Li-Yang , Email:pandarun@nxu.edu.cn