《生命科学》 2023, 35(3): 352-359

ELABELA促进心肌梗死运动康复机制

潘　收 , 席　悦^* , 田振军

陕西师范大学体育学院暨运动生物学研究所，西安 710119

摘　要：

G 蛋白偶联受体Apelin receptor (APLNR, APJ) 早期配体ELABELA/Toddler/Apela (ELA) 是一种肽类激素，对心血管系统早期发育必不可少。心肌梗死(myocardial infarction, MI) 后，ELA 表达代偿性升高，外源性ELA 干预具有靶向抑制氧化应激、细胞凋亡并促进心肌新生、抵抗MI 所致心衰的作用，对改善病理心脏重塑和提升心功能等效果显著。运动可促进内源性ELA 发挥MI 心脏的保护作用。现对ELA 结合运动干预改善氧化应激引起的细胞凋亡并缓解缺血心脏功能障碍等文献进行梳理，提出运动促进MI 心脏功能改善与康复的新观点，从而为MI 患者临床度过急性期后进行运动康复研究提供有价值的理论依据。

通讯作者：席　悦 , Email:xiyue@snnu.edu.cn

Mechanisms of ELABELA in promoting exercise rehabilitation of myocardial infarction

PAN Shou , XI Yue^* , TIAN Zhen-Jun

Institute of Sports and Exercise Biology, School of Physical Education, Shaanxi Normal University, Xi’an 710119, China

Abstract:

The G protein-coupled Apelin receptor (APLNR, APJ) and its early ligand ELABELA/Toddler/Apela
(ELA) are peptide hormones that are essential for the early development of the cardiovascular system. After myocardial infarction (MI), the expression of ELA is compensatory elevated. Exogenous ELA interventions have been shown to target oxidative stress, apoptosis and promote myocardial regeneration and resistance to MI-induced heart failure, with significant effects on improving pathological cardiac remodeling and enhancing cardiac function. Exercise can mobilize endogenous ELA to play a protective role in MI heart. This paper summarized the research reports of ELA combined with exercise intervention to improve oxidative stress-induced apoptosis and relieve ischemic cardiac dysfunction. The paper proposed a new perspective on exercise for cardiac function improvement and post-MI rehabilitation, in order to provide valuable theoretical basis for the study of exercise rehabilitation for MI patients after the acute clinical phase.

Communication Author：XI Yue , Email:xiyue@snnu.edu.cn