《生命科学》 2023, 35(3): 329-339

活菌作为智能递送载体用于肿瘤治疗的研究进展

夏　文 , 冯　卓 , 吴锦慧^*

南京大学医学院，医药生物技术国家重点实验室，南京 210093

摘　要：

细菌经常被用作药物的载体实现被装载药物的肿瘤靶向、深部组织渗透等。近年来，通过合成生物学技术对细菌的基因进行改造，赋予了细菌环境感知和响应的功能，实现了细菌负荷药物的时空调控，促进细菌作为递送载体向更加智能化的方向发展。为此，本文综述了近年来利用细菌作为药物载体，以及基于环境感知和响应控制药物释放的细菌智能递送载体应用于癌症治疗的研究进展，最后对未来智能化的细菌载体应用于癌症治疗进行展望。

通讯作者：吴锦慧 , Email:wuj@nju.edu.cn

Research advances of living bacterial intelligent delivery carriers for cancer therapy

XIA Wen , FENG Zhuo , WU Jin-Hui^*

State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China

Abstract:

Living bacteria is often used as drug carriers to achieve drug tumor targeting and deep tissue penetration. In recent years, gene modification by synthetic biology technology gave bacteria the function of environmental sensing and response, which realized the spatio-temporal regulation of bacterial drug loading, and promoted the development of bacteria as delivery carriers to a more intelligent direction. To this end, this paper reviews the recent progress on the application of bacteria as drug carriers and bacterial intelligent delivery carrier based on environmental awareness and response for the control of drug release in cancer therapy. Finally, the future application of intelligent bacterial carriers in cancer therapy is prospected.

Communication Author：WU Jin-Hui , Email:wuj@nju.edu.cn