《生命科学》 2005, 17(5):

O-超家族芋螺毒素研究进展

张 伟^1*，韩禹宏^1,2

1同济大学蛋白质研究所，上海200092；2 中国科学院上海生命科学研究院生物化学与细胞生物学研究所，中国科学院研究生院，上海 200031

摘　要：摘　要：O-超家族芋螺毒素是芋螺毒素中较复杂的超家族之一，它包括d-、mO-、w-、k-等若干成员，通常由24~33个氨基酸组成，具有相同的三对二硫键骨架，形成ICK模体，能特异性作用于电压门控离子通道。本文主要对该芋螺毒素生物化学及分子遗传学特征、生理学和药理学特征、结构与性能的关系及应用研究与前景等进行综述。
关键词：离子通道；二硫键；芋螺毒素

The progress in studies on O-superfamily conotoxins

ZHANG Wei^1*, HAN Yu-Hong^1,2

1 Institute of Protein Research, Tongji University, Shanghai 200092, China; 2 Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 200031, China

Abstract: Abstract:  O-superfamily is one of the most complex group among conotoxins, it is composed of several members such as d-, mO-, w-, k-contoxins. Usually, O-superfamily conotoxins contain 24~33 amino acid residues with three disulfide bonds. This disulfide-rich peptides can potently and selectively interfere with voltage-gated cation channels. This article reviews their characteristics of biochemistry, molecular genetics, physiology and pharmacology, relationship between structure and function, and application perspective as well.
Key words:  ion channel；disulfide bond；conotoxins