《生命科学》 2023, 35(3): 287-295

沙门氏菌抗肿瘤疗法在合成生物学时代的发展和机遇

荣　丽 , 胡叶凡 , 刘陈立 , 董宇轩 , 黄建东^*

香港大学李嘉诚医学院生物医学系，香港

摘　要：

在世界各国，癌症是导致死亡的主要原因之一，也是提高人类预期寿命的重要障碍。目前临床上主流的分子靶向疗法和免疫疗法还不能完全治愈肿瘤且常常副作用巨大，其中原因较为复杂。而以沙门氏菌抗肿瘤疗法为代表的细菌抗肿瘤疗法具有潜力弥补分子靶向疗法和免疫疗法在肿瘤靶向性上的不足。本文将从目前癌症治疗的困境出发，回顾细菌抗肿瘤疗法的历史，阐述基因工程与合成生物学时代沙门氏菌抗肿瘤疗法的进展，论述其作为下一代抗肿瘤微型机器人的潜力。最终，我们希望在靶向肿瘤治疗领域激发思想火花，克服沙门氏菌抗肿瘤疗法的局限性，推进其临床应用。

通讯作者：黄建东 , Email:jdhuang@hku.hk

The development and opportunity of Salmonella-based anti-tumor therapies in the era of synthetic biology

RONG Li , HU Ye-Fan , LIU Chen-Li , DONG Yu-Xuan , HUANG Jian-Dong^*

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

Abstract:

As one of the leading causes of death around the world, cancer is an important obstacle to increasing human lifespan. Current major cancer therapies in the clinic, represented by molecularly targeted therapy and cancer immunotherapy, usually cannot completely cure cancer and often have severe side effects. However, the bacterial anti-tumor therapy, represented by Salmonella-based anti-tumor therapy, has the potential to make up for the deficiency of molecularly targeted therapy and current cancer immunotherapy in terms of tumor-targeting. This review will start from the current predicament of cancer treatment, review the history of bacterial anti-tumor therapy, expound on the advances of Salmonella-based anti-tumor therapy in the era of genetic engineering & synthetic biology, and discuss the potential of genetically engineered Salmonella as the next generation of antitumor microrobots. Ultimately, we hope to provide a spark of thoughts in the field of tumor-targeting therapies to overcome the limitations of Salmonella-based anti-tumor therapy, and to advance its clinical applications.

Communication Author：HUANG Jian-Dong , Email:jdhuang@hku.hk