《生命科学》 2023, 35(2): 220-232

环状RNA作为潜在治疗靶点在子宫内膜异位症中的调控机制

夏芳丹¹ , 连　方^2,* , 魏超峰

¹山东中医药大学，济南 250014 ²山东中医药大学附属医院，济南 250014

摘　要：

环状RNA (circular RNAs, circRNAs) 属结构稳定的非编码RNA，具有miRNA 海绵、与蛋白质互作等生物学功能。近年，子宫内膜异位症(endometriosis， EMs；简称内异症) 中的circRNAs 逐渐得到广泛研究。诸多学者通过多种生物信息学方法预测分析出EMs 中差异表达的circRNAs、miRNAs 及相关信号通路，并对已知的差异表达的circRNA 进行敲除或过表达来探究其在上皮- 间质转化(epithelial-mesenchymal transition, EMT)、雌激素介导细胞侵袭、细胞自噬与凋亡、缺氧等生物学过程中的具体调控作用。该文以差异表达的circRNAs 为起点，从ceRNA 轴出发，在circRNA-miRNA-mRNA 网络中对参与EMs 发病的相关信号通路进行全面综述，强调了circRNAs 作为子宫内膜异位症潜在治疗靶点的作用，以期为内异症临床治疗提供新思路。

通讯作者：连　方 , Email:lianfangbangong@163.com

The regulatory mechanism of circRNAs in endometriosis as potential therapeutic targets

XIA Fang-Dan¹ , LIAN Fang^2,* , WEI Chao-Feng

¹Shandong University of Traditional Chinese Medicine, Jinan 250014, China ²Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China

Abstract:

Circular RNAs (circRNAs) are a class of non-coding RNAs with stable structure which have many biological functions such as miRNA sponge and protein interaction. In recent years, circRNAs have been studied extensively in endometriosis (EMs). Many scholars predicted and analyzed differentially expressed circRNAs and miRNAs and the related signaling pathways in EMs via a variety of bioinformatics methods. In addition, knock-out or overexpression of individual circRNA which has known differential expression also reveal it's specific regulation of epithelial mesenchymal transition (EMT), estrogen- mediated invasion, autophagy and apoptosis, hypoxia, etc. We take differentially expressed circRNAs as starting points and from the perspective of ceRNA axis, comprehensively review the relevent signaling pathways involved in the pathogenesis of EMs in the  circRNA-miRNA-mRNA network. Based on the above, we highlight the roles of circRNAs as potential therapeutic targets in endometriosis in order to provide new ideas for clinical treatment of endometriosis.

Communication Author：LIAN Fang , Email:lianfangbangong@163.com