《生命科学》 2023, 35(2): 212-219

SIRT6在动脉粥样硬化中的研究进展

袁凌志¹ , 明家萱² , 张彩平¹ , 龙石银^1,*

¹南华大学衡阳医学院生物化学与分子生物学教研室，衡阳 421001 ²南华大学衡阳医学院，衡阳 421001

摘　要：

SIRT6 是Sirtuins 家族的一员，因具有脱乙酰酶活性而参与调节能量代谢、衰老、肥胖、胰岛素抵抗、炎症等众多生物学过程。最近的研究发现SIRT6 还能通过保护内皮细胞和血管平滑肌细胞、抗炎及调节脂质代谢等发挥抑制动脉粥样硬化发生发展的作用。该文就SIRT6 在动脉粥样硬化方面的研究进展进行综述。

通讯作者：龙石银 , Email:longshiyin@126.com

Research progress of SIRT6 in atherosclerosis

YUAN Ling-Zhi¹ , MING Jia-Xuan² , ZHANG Cai-Ping¹ , LONG Shi-Yin^1,*

¹Department of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China ²Hengyang Medical College, University of South China, Hengyang 421001, China

Abstract:

SIRT6, a member of the Sirtuins family, is involved in many biological processes such as regulation of energy metabolism, aging, obesity, insulin resistance, and inflammation due to its deacetylase activity. Recent studies have found that SIRT6 can also inhibit the  development of atherosclerosis by protecting endothelial cells and vascular smooth muscle cells, anti-inflammation and regulating lipid metabolism. This article reviews the research progress of SIRT6 in atherosclerosis.

Communication Author：LONG Shi-Yin , Email:longshiyin@126.com