《生命科学》 2023, 35(2): 196-202

脂代谢重编程在肝癌恶性演进中的最新研究进展

彭柏森¹ , 周雪冰^2,3 , 杨春宇^2,3 , 陈　丹^2,3 , 任香善^2,3,*

¹延边大学医学院，延吉 133002 ²延边大学医学院病理学教研室，延吉 133002 ³延边大学肿瘤研究中心，延吉 133002

摘　要：

肝癌是一种非常常见的消化道肿瘤，其恶性程度高，发病隐匿，早期可无症状，且发病率也在逐年升高。代谢重编程是癌细胞为了满足细胞快速生长所需的大量能量，使其代谢方式发生改变。尽管与其他代谢变化( 例如葡萄糖和谷氨酰胺代谢) 相比，癌细胞中脂肪酸代谢的变化受到的关注较少，但最近的研究逐渐发现了脂类代谢重编程在癌变过程中的重要性。该文以脂代谢重编程为基础，介绍其在肝癌恶性演进中的最新进展。

通讯作者：任香善 , Email:renxsh@ybu.edu.cn

Recent advances in lipid metabolic reprogramming in the malignant evolution of liver cancer

PENG Bo-Sen¹ , ZHOU Xue-Bing^2,3 , YANG Chun-Yu^2,3 , CHEN Dan^2,3 , REN Xiang-Shan^2,3,*

¹Medical College of Yanbian University, Yanji 133002, China ²Department of Pathology, Medical College of Yanbian University, Yanji 133002, China ³Cancer Research Center of Yanbian University, Yanji 133002, China

Abstract:

Liver cancer is a very common digestive tract tumor, which is highly malignant, has an insidious onset and can be asymptomatic at an early stage, and the incidence rate is also increasing year by year. Metabolic reprogramming is the process by which cancer cells change their metabolism in order to meet the large amount of energy required for rapid cell growth. Although changes in fatty acid metabolism in cancer cells have received less attention compared with other metabolic changes, such as glucose and glutamine metabolism, recent studies have gradually uncovered the importance of lipid  metabolic reprogramming in carcinogenesis. In this review, based on lipid metabolic reprogramming, we introduce recent advances in the malignant evolution of liver cancer.

Communication Author：REN Xiang-Shan , Email:renxsh@ybu.edu.cn