《生命科学》 2023, 35(2): 165-172

脑膜淋巴管重塑在中枢神经系统疾病中的研究进展

李建涛 , 陈志毅 , 齐淑雅 , 黄青芸 , 谭国鹤^*

广西脑科学研究重点实验室，广西医科大学神经科学研究所，广西医科大学基础医学院人体解剖学教研室，南宁 530021

摘　要：

近年来，随着脑膜淋巴管(meningeal lymphatic vessels, MLVs) 研究的进一步深入，越来越多的证据表明MLVs 在中枢神经系统疾病的发生发展中扮演着重要角色，而血管内皮生长因子C (vascular endothelial growth factor-C, VEGF-C)/ 血管内皮生长因子受体3 (vascular endothelial growth factor receptor-3, VEGFR-3) 信号通路在MLVs 重塑中起到重要作用。本文拟对VEGF-C/VEGFR-3 信号通路的作用机制及其介导的MLVs 重塑在阿尔茨海默病、多发性硬化症、创伤性脑损伤等中枢神经系统疾病的发病和进展中的作用进行综述，旨在为中枢神经系统疾病的治疗提供新策略。

通讯作者：谭国鹤 , Email:tanguohe@gxmu.edu.cn

Research progress of meningeal lymphatic vessels remodeling in central nervous system diseases

LI Jian-Tao , CHEN Zhi-Yi , QI Shu-Ya , HUANG Qing-Yun , TAN Guo-He^*

Department of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China

Abstract:

In recent years, as meningeal lymphatic vessels(MLVs) have been further investigated, there is increasing evidence that MLVs are critical to the pathological progression of central nervous system diseases. Vascular endothelial growth factor C/vascular endothelial growth factor receptor 3 (VEGF-C/VEGFR-3) signaling pathway is a critical regulator of MLVs remodeling. The purpose of this paper is to review the mechanism of the VEGF-C/VEGFR-3 signaling pathway and its mediated MLVs remodeling in the pathogenesis and progression of central nervous system diseases such as Alzheimer's disease, multiple sclerosis, traumatic brain injury, and to look forward to manipulating MLVs’ function as a new therapeutic strategy for treatment of central nervous system diseases.

Communication Author：TAN Guo-He , Email:tanguohe@gxmu.edu.cn