《生命科学》 2023, 35(2): 123-131

非组蛋白巴豆酰化修饰的生物学功能研究进展

庞攀攀¹ , 杨铁花¹ , 郑永唐² , 郑昌博^3,*

¹云南中医药大学中药学院暨云南省南药可持续利用研究重点实验室，昆明 650500 ²中国科学院昆明动物研究所，中国科学院动物模型与人类疾病机理重点实验室，昆明 650223 ³昆明医科大学药学院暨云南省天然药物药理重点实验室，昆明 650500

摘　要：

赖氨酸巴豆酰化是一种新近发现的蛋白质翻译后修饰类型，在基因表达、细胞代谢及疾病治疗等许多病理生理过程中都具有重要的调节意义，可能是潜在的药物新靶标。目前研究多关注于组蛋白巴豆酰化修饰，而非组蛋白巴豆酰化修饰的研究逐渐被重视。本文简要介绍非组蛋白巴豆酰化修饰的生物学功能及其在疾病中的作用，将有助于了解非组蛋白巴豆酰化修饰的功能和机制。

通讯作者：郑昌博 , Email:zhengchangbo@kmmu.edu.cn

Progress in biological functions of crotonylation modification of non-histone proteins

PANG Pan-Pan¹ , YANG Tie-Hua¹ , ZHENG Yong-Tang² , ZHENG Chang-Bo^3,*

¹College of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China ²Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China ³School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China

Abstract:

Lysine crotonylation is a newly discovered type of protein post-translational modification, which has important regulatory significance in many pathophysiological  processes such as gene expression, cell metabolism and disease treatment, and may be a potential new drug  target. At present, most of the research focuses on  histone crotonylation modification, while the research on non-histone crotonylation modification has gradually attracted more attention. In this paper, we briefly introduce the biological function of non-histone crotonylation modifications and their role in diseases, aiming to help to understand the function and mechanisms of non-histone crotonylation modifications.

Communication Author：ZHENG Chang-Bo , Email:zhengchangbo@kmmu.edu.cn