《生命科学》 2022, 34(12): 1550-1558

奇壬醇的功能及抗炎作用机制研究进展

张　梦^1,2 , 沈小芳^1,2 , 翟立红^1,2 , 肖　娟^1,2,*

¹湖北文理学院医学部分子医学实验室，襄阳 441053 ²湖北文理学院附属 医院襄阳市中心医院，神经科学与脑科学研究所，襄阳 441021

摘　要：

奇壬醇(kirenol, kir) 是从传统抗风湿药豨莶草中提取的活性成分，因其具有广泛的药理学活性，近几年引起国内外科研工作者的研究兴趣。现代临床前研究证实kir 具有多种生物学活性，包括抑制细胞生长、促凋亡、抗炎、心脏保护、抗光老化、抗脂肪生成、抗菌、改善肌肉功能、抗关节炎、促进骨折和伤口愈合等。大量研究发现kir 通过调节NF-κB 和Nrf2 在各种体内和体外疾病模型中发挥抗炎作用，提示抗炎是kir 的主要生物学功能。该文综合分析近年来发表的研究成果，总结kir 的生物学功能和抗炎分子机制、应用前景及不足，为kir 的下一步基础研究和临床应用研究提供线索。

通讯作者：肖　娟 , Email:ju_126@126.com

The research progress on the function and anti-inflammatory mechanisms of kirenol

ZHANG Meng^1,2 , SHEN Xiao-Fang^1,2 , ZHAI Li-Hong^1,2 , XIAO Juan^1,2,*

¹Department of Molecular Medicine Laboratory, Hubei University of Arts and Science, Xiangyang 441053, China ²Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China

Abstract:

Kirenol (kir) is an active ingredient extracted from Herba Siegesbeckiae which is a traditional
antirheumatic herb in China. In recent years, kir has attracted the interests of researchers for its extensive pharmacological activity. Modern preclinical studies have confirmed that kir has a variety of biological activities, including inhibiting cell growth, promoting apoptosis, anti-inflammation, cardiac protection, anti-photoaging, antiadipogenesis, antibacterial, muscle improvement, anti-arthritis, promoting fracture and wound healing, etc. Many studies have found that kir plays an anti-inflammatory role in vivo and in vitro by regulating NF-κB and Nrf2, suggesting that anti-inflammation is the main biological function of kir. This paper comprehensively analyzed the research results published in recent years, summarized the biological function and anti-inflammatory molecular mechanisms of kir, and analyzed its application prospects and limitations, in order to provide clues for the future preclinical and clinical researches on kir.

Communication Author：XIAO Juan , Email:ju_126@126.com