《生命科学》 2022, 34(12): 1506-1518

骨骼肌质膜修复相关蛋白研究进展

吴柏乐 , 吴　迎^*

北京体育大学运动人体科学学院，北京 100091

摘　要：

质膜修复(plasma membrane repair, PMR) 是细胞存活及正常生理活动的重要保障。骨骼肌细胞易受机械刺激引发质膜损伤，及时有效的质膜修复是维持骨骼肌细胞功能的关键。此外，骨骼肌质膜修复缺陷也是肌营养不良症的主要病理特点。该文从骨骼肌生理和病理角度出发，对参与PMR 的相关蛋白进行全面综述，系统梳理了PMR 相关蛋白在骨骼肌损伤修复中的特点及协同效应，总结并归纳了骨骼肌PMR的理论模型，为膜修复蛋白在PMR 中作用机制的深入研究提供新思路。

通讯作者：吴　迎 , Email:wuying@bsu.edu.cn

Research progress of proteins related to skeletal muscle plasma membrane repair

WU Bai-Le , WU Ying^*

College of Sport Science, Beijing Sport University, Beijing 100091, China

Abstract:

Plasma membrane repair (PMR) is an important guarantee for cell survival and normal physiological activities. Skeletal muscle cells are susceptible to plasma membrane damage caused by mechanical stimuli, and timely and effective PMR is essential to maintain skeletal muscle cell function. In addition, defective skeletal muscle PMR is also a major pathological feature of myotonic dystrophy. This paper presents a comprehensive review of the relevant proteins involved in PMR from the perspective of skeletal muscle physiology and pathology, systematically sorting out the characteristics and synergistic effects of PMR-related proteins in skeletal muscle injury repair, summarizing and generalizing the theoretical model of PMR in skeletal muscle, to provide new ideas for the in-depth study of the mechanism of membrane repair proteins in PMR.

Communication Author：WU Ying , Email:wuying@bsu.edu.cn