《生命科学》 2022, 34(12): 1485-1492

腺苷及其受体在皮肤创面愈合与纤维化中的作用

马久程¹ , 王兆楠¹ , 殷　栋¹ , 奚铭凡¹ , 祁　俊^2,*

¹南通大学医学院，南通 226000 ²南通大学附属医院烧伤整形科，南通 226000

摘　要：

皮肤的急慢性创面在临床上较常见，个体差异性大，且慢性创面治疗较为棘手；此外，皮肤纤维化疾病日渐增多，而现有治疗方式效果欠佳。因此，亟需寻找一种新的皮肤创面及纤维化治疗策略。腺苷在创面愈合和组织修复过程中起着重要作用，腺苷可通过激活其受体抑制炎症反应、促进血管生成、促进胶原合成，加速创面愈合，但腺苷受体的过度激活也可刺激成纤维细胞及胶原的异常增殖介导皮肤纤维化形成。该文就腺苷及其受体在皮肤创面愈合及纤维化中的作用作一综述，有望为再生医学的治疗策略提供一定思路及应用价值。

通讯作者：祁　俊 , Email:qijunsky@126.com

Adenosine and its receptors in skin wound healing and fibrosis

MA Jiu-Cheng¹ , WANG Zhao-Nan¹ , YIN Dong¹ , XI Ming-Fan¹ , QI Jun^2,*

¹Nantong University Medical School, Nantong 226000, China ²Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong 226000, China

Abstract:

Acute and chronic skin wounds are clinically common, with large individual differences, and the treatment of chronic wounds is more difficult. In addition, skin fibrosis related diseases have grown immensely, while existing treatment modalities are less effective. Therefore, there is a great need to find a new treatment strategy for skin wounds and fibrosis. Adenosine plays an important role in wound healing and tissue repair processes, and adenosine can inhibit inflammatory responses, promote angiogenesis, and promote collagen synthesis to accelerate wound healing by activating its receptors. However, excessive activation of adenosine receptors can also stimulate abnormal proliferation of fibroblasts and collagen to mediate dermal fibrogenesis. This review focuses on the roles of adenosine and its receptors in skin wound healing and fibrosis, which will hopefully provide some ideas and applications for the regenerative medicine treatment strategies.

Communication Author：QI Jun , Email:qijunsky@126.com