《生命科学》 2022, 34(11): 1386-1393

Wnt/β-catenin通路在肿瘤免疫和免疫治疗中的研究进展

李康华^1,2,3 , 李星星² , 吴　凡² , 王　进^2,* , 解　伟^2,3,4,*

¹上海理工大学医疗器械与食品学院，上海 200093 ²上海健康医学院药学院，上海 201318 ³上海健康医学 院附属嘉定中心医院上海市分子影像学重点实验室，上海 201318 ⁴上海理工大学研究生院，上海 200093

摘　要：

异常激活的Wnt/β-catenin 信号通路可诱导恶性肿瘤的发生发展并介导肿瘤免疫逃逸。该通路抑制剂已被证明可促进免疫细胞在肿瘤组织的浸润和激活，并且可以与免疫检查点抑制剂联合提高其治疗效果，提示干预Wnt/β-catenin 信号通路是免疫治疗的有益补充。该文就Wnt/β-catenin 信号通路在免疫细胞的发育、功能和激活等方面的作用进行总结，并讨论了肿瘤细胞中异常激活的Wnt/β-catenin 信号通路通过促进免疫检查点的表达等途径诱导肿瘤免疫逃逸，接着对Wnt/β-catenin 信号通路抑制剂在免疫治疗中的研究进展做了综述，进一步丰富Wnt/β-catenin 信号通路参与肿瘤免疫的理论，并为以Wnt/β-catenin 通路开发免疫治疗药物提供新的思路。

通讯作者：王　进 , Email:jierawang@126.com 解　伟 , Email:xiewei22400@126.com

Research progress of Wnt/β-catenin pathway in tumor immunity and immunotherapy

LI Kang-Hua^1,2,3 , LI Xing-Xing² , WU Fan² , WANG Jin^2,* , XIE Wei^2,3,4,*

¹School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China ²School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China ³Shanghai Key Laboratory of Molecular Imaging, Jiading Central Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201318, China ⁴Graduate School of University of Shanghai for Science and Technology, Shanghai 200093, China

Abstract:

Abnormally activated Wnt/β-catenin signaling pathway can induce the occurrence and development of malignant tumors and mediate tumor immune escape. Inhibitors of this pathway have been shown to promote the infiltration and activation of immune cells in tumor tissues, and can be combined with immune checkpoint inhibitors to improve their therapeutic efficacy, suggesting that intervention of Wnt/β-catenin signaling pathway is a beneficial complement to immunotherapy. This article summarizes the role of Wnt/β-catenin signaling pathway in the development, function and activation of immune cells, and discusses that abnormally activated Wnt/β-catenin signaling pathway in tumor cells induces tumor immune escape by promoting the expression of immune checkpoints. Then, the research progress of Wnt/β-catenin signaling pathway inhibitors in immunotherapy is reviewed. It is intended to further enrich the theory of Wnt/β-catenin signaling pathway involved in tumor immunity, and provide new ideas for the development of immunotherapeutic drugs using Wnt/β-catenin pathway.

Communication Author：WANG Jin , Email:jierawang@126.com XIE Wei , Email:xiewei22400@126.com