《生命科学》 2022, 34(11): 1378-1385

脂肪酸去饱和途径在肿瘤发生发展中的作用

李旭辉¹ , 黄信羽² , 李嘉懿² , 赵　健^2,* , 梁蓓蓓^2,*

¹上海理工大学健康科学与工程学院，上海 200093 ²上海健康医学院药学院， 上海健康医学院附属嘉定中心医院上海市分子影像学重点实验室，上海 201318

摘　要：

肿瘤的发生发展与肿瘤代谢异常密切相关。近几年，脂肪酸代谢在肿瘤代谢研究中越来越受到关注，脂肪酸的合成代谢在肿瘤细胞的生长、转移和化疗效果提升中发挥关键性的作用。脂肪酸除了作为细胞膜基质结构成分外，还是重要的二级信使，同时可以作为机体能量的来源。不饱和脂肪酸由饱和脂肪酸通过去饱和途径作用转化而来。由硬脂酰辅酶A 去饱和酶(SCD) 所催化的单不饱和脂肪酸是生物体细胞膜必需的组分之一。肿瘤细胞脂肪酸代谢中的去饱和途径由于新的替代方式的出现近年来备受关注，即由脂肪酸去饱和酶2 (FADS2)介导生成sapienate 的去饱和途径。该文综述归纳总结了脂肪酸去饱和途径中关键酶(SCD和FADS2) 及甾醇调节元件结合蛋白1 (SREBP1) 在肿瘤的发生发展中的作用及最新研究，旨在对基于肿瘤脂肪酸代谢的治疗及调控靶点进行进一步的挖掘和探索。

通讯作者：赵　健 , Email:zj_xd@126.com 梁蓓蓓 , Email:liangbb@sumhs.edu.cn

The role of fatty acid desaturation in tumorigenesis and progression

LI Xu-Hui¹ , HUANG Xin-Yu² , LI Jia-Yi² , ZHAO Jian^2,* , LIANG Bei-Bei^2,*

¹School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China ²Shanghai Key Laboratory of Molecular Imaging, Jiading Central Hospital, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

Abstract:

The tumor abnormal metabolism is closely related to tumorigenesis and progression. Fatty acid
metabolism has received increasing attention in tumor metabolism research in recent years. Fatty acid synthesis plays a key role in tumor growth, metastasis and chemotherapy. In addition to being a structural component of the cell membrane, fatty acids are important secondary messengers and can also serve as a source of energy for the body. Unsaturated fatty acids are converted from saturated fatty acids through desaturation. Monounsaturated fatty acids are one of the components necessary for the production of cell membranes. The pathway of fatty acid desaturation in tumor cells has received much attention in recent years due to the emergence of new alternative regulation, some cancer cells desaturate palmitate to sapienate via fatty acid desaturase 2 (FADS2). This review summarizes the research of key enzymes [stearoyl-CoA desaturase (SCD) and FADS2] and sterol-regulatory element binding protein 1 (SREBP1) in the pathway of fatty acid desaturation in tumor development. It aims to further explore the therapeutic and regulatory targets based on tumor fatty acid metabolism.

Communication Author：ZHAO Jian , Email:zj_xd@126.com LIANG Bei-Bei , Email:liangbb@sumhs.edu.cn