《生命科学》 2022, 34(11): 1342-1350

机械力调节细胞功能影响创面愈合的研究进展

谢苏杰¹ , 李子键¹ , 胡守一² , 张佳怡² , 仵敏娟^3,*

¹海军军医大学基础医学院一大队，上海 200433 ²海军军医大学基础医学院三大队， 上海 2004333 ³海军军医大学基础医学院组织胚胎学教研室，上海 200433

摘　要：

创面愈合是指机体遭受外力作用，皮肤组织出现离断或缺损后愈合恢复的连续过程，包括各种组织再生、肉芽组织增生和瘢痕形成。创面愈合涉及多个细胞群、细胞外基质和各种信号分子，可以分为3个阶段：止血与炎症期、增殖期和重塑期。机械力作为细胞结构和功能的调节因素，参与调节创面愈合中多个细胞群的增殖、迁移和分化等生理过程，影响创面愈合的进程。现从细胞角度讨论机械力对创面愈合的影响。

通讯作者：仵敏娟 , Email:minjuanwu@163.com

Research progress on mechanical forces regulating cell function in wound healing

XIE Su-Jie¹ , LI Zi-Jian¹ , HU Shou-Yi² , ZHANG Jia-Yi² , WU Min-Juan^3,*

¹Brigade One Team, Basic Medical College, Naval Medical University, Shanghai 200433, China ²Brigade Three Team, Basic Medical College, Naval Medical University, Shanghai 200433, China ³Department of Histology and Embryology, Basic Medical College, Naval Medical University, Shanghai 200433, China

Abstract:

Wound healing is the continuous process of healing and restoring skin tissue after the body has been subjected to external forces, which includes various forms of tissue regeneration, granulation tissue hyperplasia and scar formation. Wound healing involves multiple cell populations, extracellular matrix and various signaling molecules. This process can be divided into 3 phases: hemostasis and inflammation, proliferation and remodeling. As regulators of cell structure and function, mechanical forces participate in regulating physiological processes such as proliferation, migration and differentiation of multiple cell groups in wound healing, affecting the process of wound healing. This review summarizes the effect of mechanical forces on wound healing from the cellular perspective.

Communication Author：WU Min-Juan , Email:minjuanwu@163.com