《生命科学》 2022, 34(9): 1190-1198

天然产物EGCG作为肿瘤辅助治疗药物的分子机制及其应用研究进展

苟　惠¹ , 陈　平² , 耿瑞蔓³ , 刘　戟³ , 吴文兵^4,*

¹西南医科大学附属医院，药学部，泸州 646000 ²遂宁市中心医院，药学部，遂宁 629000 ³四川大学华西基础医学与法医学院，生物化学与分子生物学教研室，成都 610041 ⁴西南医科大学基础医学院，生物化学与分子生物学教研室，泸州 646000

摘　要：

表没食子儿茶素-3- 没食子酸酯(epigallocatechin-3-gallate, EGCG) 是绿茶的主要活性成分，具有抑制氧化应激和炎症、降低血脂和血糖的功能。近年来，EGCG 的抗肿瘤活性受到人们的广泛关注。EGCG和其他多酚类物质常被用作辅助抗癌药物，在与常规治疗手段如化疗/ 放射治疗相结合时，EGCG 能发挥增敏剂的作用，并能改善放化疗治疗肿瘤时产生的副作用。该文将概述EGCG 抗肿瘤的机制、作为肿瘤辅助治疗药物的应用及其局限性，以及未来的研究方向，为EGCG 的抗肿瘤研究和应用提供参考。

通讯作者：吴文兵 , Email:wuwenbing5@vip.163.com

Research progress in molecular mechanism and application of natural product EGCG as a tumor adjuvant therapeutic agent

GOU Hui¹ , CHEN Ping² , GENG Rui-Man³ , LIU Ji³ , WU Wen-Bing^4,*

¹Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China ²Department of Pharmacy, Suining Central Hospital, Suining 629000, China ³Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China ⁴Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China

Abstract:

Epigallocatechin-3-gallate (EGCG) is the main active component of green tea, which has the functions of inhibiting oxidative stress and inflammation, lowering blood lipid and blood sugar. In recent years, the antitumor activity of EGCG has received extensive attention. EGCG and other polyphenols are often used as adjuvant anticancer drugs. When combined with conventional treatments such as chemotherapy/radiotherapy, EGCG can act as a sensitizer and reduce the side effects of radiotherapy and chemotherapy for tumors. This article will outline the anti-tumor mechanism of EGCG, the application and limitations of EGCG as an adjuvant tumor therapy drug, and the future research direction, so as to provide reference for the anti-tumor research and application of EGCG.

Communication Author：WU Wen-Bing , Email:wuwenbing5@vip.163.com