《生命科学》 2022, 34(9): 1181-1189

冷诱导RNA结合蛋白在多种应激反应中的作用

曹宏伟¹ , 黄清宇² , 张　蕾^1,*

¹天津大学生命科学学院，天津 300072 ²内蒙古大学生命科学学院，呼和浩特 010021

摘　要：

冷诱导RNA 结合蛋白(cold-inducible RNA-binding protein, CIRBP) 为最早在哺乳动物中发现的冷休克蛋白，可伴随温和低温、缺氧、紫外线照射等条件而大量表达，是一种参与多个生物学和疾病过程的应激反应蛋白。在应激条件下，CIRBP 可上调自身表达，并从细胞核向细胞质转移，通过稳定特定的mRNA 促进其翻译，使细胞对环境信号做出快速反应，帮助细胞适应新的环境条件。该文针对应激条件下CIRBP 的表达调控以及CIRBP 参与促炎症、肿瘤发生、抗凋亡过程中的应激反应的新发现加以综述，阐述CIRBP 在细胞应激反应中的可能机制，希望利用该蛋白的相关功能为有关疾病的诊治提供理论基础。

通讯作者：张　蕾 , Email:zhanglei@tju.edu.cn

The role of cold-inducible RNA binding protein in a variety of stress reactions

CAO Hong-Wei¹ , HUANG Qing-Yu² , ZHANG Lei^1,*

¹School of Life Sciences, Tianjin University, Tianjin 300072, China ²School of Life Sciences, Inner Mongolia University, Hohhot 010021, China

Abstract:

Cold-inducible RNA-binding protein (CIRBP) was the first cold shock protein found in mammals, which could be highly expressed with mild low temperature, hypoxia, ultraviolet radiation and other conditions. CIRBP was a stress-response protein involved in many biological and disease processes. Under stress conditions, CIRBP could up-regulate its expression and relocated into cytoplasm from nucleus, which enabled cells to respond quickly and adapt to changing environmental conditions by stabilizing specific mRNA and promoting its translation. This review summarized the recent discoveries in the regulation of CIRBP expression under pressure and its involvement in stress response during pro-inflammation, anti-apoptosis and tumorigenesis. In addition, the possible mechanism of CIRBP in cell stress response was discussed, which provided theoretical basis for the diagnosis and treatment of related diseases.

Communication Author：ZHANG Lei , Email:zhanglei@tju.edu.cn