《生命科学》 2022, 34(9): 1126-1134

星形胶质细胞有氧糖酵解及其产物乳酸在阿尔茨海默病突触可塑性中的作用

王亚鑫^1,2 , 赵　丽^1,2,*

¹北京体育大学运动生理学教研室，北京 100084 ²北京体育大学运动与体质健康教育部重点实验室，北京 100084

摘　要：

脑内糖酵解代谢障碍已逐渐被认为是阿尔茨海默病(Alzheimer’s disease, AD) 的一种病因。星形胶质细胞是中枢神经系统有氧糖酵解的主要场所，其糖酵解产物乳酸通过星形胶质细胞- 神经元乳酸穿梭系统进入神经元内供能或作为信号分子影响AD 的突触可塑性。该文总结了糖酵解与AD 病理特征的关系以及星形胶质细胞糖酵解对AD 突触可塑性的影响，并且进一步讨论了乳酸在突触可塑性中发挥的作用。希望将乳酸穿梭作为一种治疗策略，旨在对抗AD 的神经退行性风险。

通讯作者：赵　丽 , Email:zhaolispring@126.com

The role of astrocyte aerobic glycolysis and its product lactate in synaptic plasticity in Alzheimer’s disease

WANG Ya-Xin^1,2 , ZHAO Li^1,2,*

¹Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China ²Key Laboratory of Sports and Physical Health Ministry of Education, Beijing Sport University, Beijing 100084, China

Abstract:

Glycolysis impairment within the brain has been increasingly recognized as a cause of Alzheimer’s disease (AD). Astrocytes are the main site of aerobic glycolysis in the central nervous system, and lactate, the predominant end product of glycolysis, has recently been identified as an energy supplier or signaling molecule for synaptic plasticity via the astrocyte-neuron lactate shuttle system. In this review, we summarized the relationship between glycolysis and pathological features of AD and the effect of astrocyte glycolysis on synaptic plasticity in AD. We further discussed the role of lactate in synaptic plasticity, hoping to use lactate shuttle as a therapeutic strategy aiming at combating the neurodegenerative risk of AD.

Communication Author：ZHAO Li , Email:zhaolispring@126.com