《生命科学》 2022, 34(8): 1054-1063

心脏与骨骼肌Smyd1及其运动干预研究进展

唐　杰 , 蔡梦昕^* , 田振军

陕西师范大学体育学院暨运动生物学研究所，西安 710119

摘　要：

组蛋白甲基转移酶1 (SET and MYND domain containing 1, Smyd1) 是组蛋白赖氨酸甲基转移酶SMYD 家族成员，其表达具有肌组织特异性，可通过甲基化组蛋白和非组蛋白，在转录水平调控靶基因表达，参与细胞结构组成和生理活动。研究发现，Smyd1 是调节心脏和骨骼肌发育的关键因子之一，在肌节组装、肌细胞生长和线粒体能量代谢等过程中发挥重要生物学作用，其表达异常与多种心脏和骨骼肌疾病的发生发展密切相关。运动可促进心脏和骨骼肌生长发育和功能改善，同时调节正常生理和病理条件下Smyd1 表达。Smyd1 是否可作为运动作用的靶点，通过调控其下游分子和表观遗传改变，参与运动效应值得研究。本文对近年来Smyd1 的生物学表征及其在心脏和骨骼肌发育和成体功能维持中的作用进行梳理，对其运动干预效应进行总结和展望，以期为临床心脏和骨骼肌疾病的治疗靶点及运动训练和康复干预的作用靶点筛选研究提供理论依据。

通讯作者：蔡梦昕 , Email:warmxin123@126.com

The role of histone methyltransferase Smyd1 in heart and skeletal muscle and impact of exercise intervention

TANG Jie , CAI Meng-Xin^* , TIAN Zhen-Jun

Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi’an 710119, China

Abstract:

Smyd1 (SET and MYND domain containing 1), a member of the histone lysine methyltransferase SMYD family, is a muscle-specific protein. Through methylating histone and non-histone proteins at the transcriptional level, Smyd1 plays an important role in maintaining cell structure and function. It has been reported that Smyd1 is a key factor in the development of heart and skeletal muscle by regulating sarcomere assembly, muscle fiber growth and mitochondrial energy metabolism. The abnormal expression of Smyd1 is closely related to the occurrence and development of a variety of heart or skeletal muscle diseases. Exercise can improve the development and growth of heart and skeletal muscle and regulate Smyd1 expression under physiological and pathological conditions. In this article, we review the biological characterization and function of Smyd1, summarize and prospect the effect of exercise intervention, thus trying to provide a theoretical basis for exploring the therapeutic targets of heart and skeletal muscle diseases and the mechanism of exercise intervention.

Communication Author：CAI Meng-Xin , Email:warmxin123@126.com