《生命科学》 2022, 34(7): 790-805

肿瘤与心力衰竭相关性研究进展

杜艳涛¹ , 吴　涛^2,*

¹宁波大学医学院附属医院，宁波市医学科学研究所，宁波 315020； ²宁波大学医学院附属医院，心血管内科，宁波 315020

摘　要：

肿瘤和心力衰竭是全球死亡率最高的两类常见疾病。流行病学数据显示，肿瘤患者心力衰竭发生率逐年攀升，心力衰竭患者肿瘤易患性也逐年增高，提示二者存在密切相关性与潜在的关联机制。二者关联机制涉及神经内分泌激活、慢性炎症、氧化应激等病理生理学机制以及共同的危险因素。该文将对肿瘤与心力衰竭的临床相关性和关联机制进行综述，以期对肿瘤心脏病学的基础研究和临床实践提供线索和思路。

 

通讯作者：吴　涛 , Email:wutao@nbu.edu.cn

The research progression of the relationship between cancer and heart failure

DU Yan-Tao¹ , WU Tao^2,*

¹Ningbo Institute of Medical Science, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China ²Department of Cardiology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China

Abstract:

Cancer and heart failure are both the most common diseases with the highest mortality rates worldwide. Epidemiological data show that the incidence of heart failure in cancer patients is gradually increasing, and the incidence of new-onset cancer in patients with heart failure is also increasing year by year, indicating a close correlation and intrinsic link between cancer and heart failure. The correlation mechanisms are referred to several common pathophysiological mechanisms, including neuro-hormonal activation, inflammation, and oxidative stress, in combination with risk factors. We herein review the clinical relevance and the correlation mechanisms of cancer and heart failure, which are expected to provide clues and ideas on the basic research and clinical practice of oncocardiology.

Communication Author：WU Tao , Email:wutao@nbu.edu.cn