《生命科学》 2022, 34(6): 692-701

巨噬细胞在动脉粥样硬化中的不同分型及其功能的研究进展

金晟康 , 左　群^*

上海体育学院运动科学学院，上海 200438

摘　要：

动脉粥样硬化是多种心血管疾病的病理学基础，而巨噬细胞则是其病理发展过程中主要参与的免疫细胞。根据机体微环境的改变，巨噬细胞可以极化成不同的表型，在动脉粥样硬化病理发展过程中发挥相应的生理功能，如经典活化的M1 型和替代活化的M2 型。随着研究的不断深入，在动脉粥样硬化中进一步发现了如M2a、M2b、M2c、Mox、HA-mac、Mhem、M(hb)、M4 型等不同表型的巨噬细胞。该文综述了巨噬细胞的最新起源、在动脉粥样硬化中的极化分型等研究进展，并归纳不同表型巨噬细胞的表达标记与功能。

通讯作者：左　群 , Email:zq2018@sus.edu.cn

Research progress of macrophage phenotypes and their functions in arteriosclerosis

JIN Sheng-Kang , ZUO Qun^*

School of Sports Science, Shanghai University of Sports, Shanghai 200438, China

Abstract:

Atherosclerosis is the pathological basis of several cardiovascular diseases and macrophages are the primary immune cells involved in the entire process. Macrophages can polarize into multiple phenotypes to perform corresponding physiological functions in all stages of arteriosclerosis, such as the classically activated macrophages M1 and alternatively activated macrophages M2, based on changes in the microenvironment of the body system. Further research has identified additional plaque-specific macrophage phenotypes known as M2a, M2b, M2c, Mox, HA-mac, Mhem, M (Hb), and M4. This article summarizes our current understandings of macrophages' most recent origins, the classification of their phenotypes in atherosclerosis, and their expression markers and functions.

Communication Author：ZUO Qun , Email:zq2018@sus.edu.cn