《生命科学》 2022, 34(5): 573-580

tsRNAs的生物学功能及与疾病关系的研究进展

任峻松 , 柏　文 , 姚牧笛 , 赵　雅 , 蒋　沁^*

南京医科大学附属眼科医院，南京 210029

摘　要：

tRNA 衍生的小RNA (tRNA-derived small RNAs, tsRNAs) 是一种来源于成熟tRNA 或前体tRNA 的非编码小RNA，广泛存在于多种物种中，主要分为tRNA 衍生片段(tRNA-derived RNA fragments, tRFs) 和tRNA 半分子(tRNA halves, tiRNAs) 两大类。近年来，随着生物信息学工具及RNA 高通量测序技术的快速发展，tsRNAs 的生物学功能以及在不同疾病病理生理中的作用被广泛研究，已成为非编码RNA 领域的前沿热点。该文就tsRNAs 的产生与分类、生物学功能，以及与疾病的关系和其潜在应用进行综述。

通讯作者：蒋　沁 , Email:jqin710@vip.sina.com

Advances in the biological function of tsRNAs and its relationship with diseases

REN Jun-Song , BAI Wen , YAO Mu-Di , ZHAO Ya , JIANG Qin^*

The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, China

Abstract:

tRNA-derived small RNAs (tsRNAs) is a kind of non-coding small RNAs derived from mature tRNA or pre-tRNA, and exists widely in many species. It is mainly divided into two categories: tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs). In recent years, with the rapid development of bioinformatics tools and RNA high-throughput sequencing technology, the biological function of tsRNAs and its role in the pathophysiology of different diseases have been widely studied, which has become a research frontier hotspot in the field of non-coding RNA. This review focuses on the generation and classification of tsRNAs, the biological functions, the relationship with diseases and their potential application.

Communication Author：JIANG Qin , Email:jqin710@vip.sina.com